Indications for Diphenoxylate HCl/Atropine Sulfate Oral Solution:
Adjunct therapy in the management of diarrhea.
10mL 4 times daily until diarrhea is controlled; max 20mg/day. Maintenance: 10mL daily. Discontinue if no improvement within 10 days after treatment with max dose.
See full labeling. <2yrs: not recommended. 2–12yrs: initially 0.3–0.4mg/kg in 4 divided doses until diarrhea is controlled. Maintenance: 25% of initial dose; max 48hrs.
Diphenoxylate HCl/Atropine Sulfate Oral Solution Contraindications:
Obstructive jaundice. Diarrhea associated with pseudomembranous enterocolitis or other enterotoxin-producing bacteria.
Diphenoxylate HCl/Atropine Sulfate Oral Solution Warnings/Precautions:
Dehydration. Electrolyte imbalance. Acute ulcerative colitis; discontinue if toxic megacolon occurs. Hepatic or renal impairment. Drug abusers. Pregnancy (Cat.C). Nursing mothers.
Diphenoxylate HCl/Atropine Sulfate Oral Solution Classification:
Opioid + anticholinergic.
Diphenoxylate HCl/Atropine Sulfate Oral Solution Interactions:
Concomitant MAOIs may cause hypertensive crisis; avoid use. Potentiates sedation with alcohol, CNS depressants (eg, barbiturates, tranquilizers). May delay elimination of other drugs metabolized by CPY450.
Nausea, vomiting, abdominal discomfort, paralytic ileus, toxic megacolon, dizziness, drowsiness, headache, euphoria, tachycardia, numbness of extremities, pruritus, urticaria, angioneurotic edema, anticholinergic effects; respiratory depression (overdosage), atropinism (esp in pediatrics with Down's syndrome).