Diltiazem Hcl Injection

  • CHF and arrhythmias

Diltiazem Hcl Injection Generic Name & Formulations

General Description

Diltiazem HCl 5mg/mL; soln for IV inj or infusion after dilution.

Pharmacological Class

Calcium channel blocker (CCB) (benzothiazepine).

How Supplied

Contact supplier.

Diltiazem Hcl Injection Indications


Temporary control of rapid ventricular rate in atrial fibrillation or flutter. Rapid conversion of paroxysmal supraventricular tachycardias (PSVT) to sinus rhythm.

Diltiazem Hcl Injection Dosage and Administration


Direct IV single injections (bolus): initially 0.25mg/kg over 2 minutes; if needed, may give second dose (0.35mg/kg) after 15 minutes; subsequent bolus doses should be individualized. If continuous IV infusion is needed, begin immediately after bolus administration. Initial infusion rate: 10mg/h; may increase in 5mg/h increments up to 15mg/h. May be maintained for up to 24 hours.


Not recommended.

Diltiazem Hcl Injection Contraindications


Sick sinus syndrome or 2nd- or 3rd-degree AV block (unless paced). Severe hypotension. Cardiogenic shock. Concomitant IV β-blockers. Atrial fibrillation or flutter associated with an accessory bypass tract such as in Wolff-Parkinson-White syndrome or short PR syndrome. Ventricular tachycardia.

Diltiazem Hcl Injection Boxed Warnings

Not Applicable

Diltiazem Hcl Injection Warnings/Precautions


Have resuscitative equipment readily available. CHF. Renal or hepatic impairment. Hemodynamically compromised. Continuously monitor ECG and blood pressure. Pregnancy (Cat.C). Nursing mothers: not recommended.

Diltiazem Hcl Injection Pharmacokinetics

See Literature

Diltiazem Hcl Injection Interactions


See Contraindications. Possible bradycardia, AV block, and/or depression of contractility with concomitant oral β-blockers. Additive effects with agents known to affect cardiac conduction. Avoid concomitant CYP3A4 inducers (eg, rifampin). Potentiated by cimetidine; may need to adjust diltiazem dose. May potentiate anesthetics, benzodiazepines, buspirone, carbamazepine, cyclosporine, quinidine; monitor.

Diltiazem Hcl Injection Adverse Reactions

Adverse Reactions

Hypotension, inj site reactions (eg, itching, burning), vasodilation, arrhythmia; dermatological events (eg, erythema multiforme, exfoliative dermatitis; discontinue if occurs), hepatotoxicity, ventricular premature beats.

Diltiazem Hcl Injection Clinical Trials

See Literature

Diltiazem Hcl Injection Note


Formerly known under the brand name Cardizem.

Diltiazem Hcl Injection Patient Counseling

See Literature