Diflucan 150mg

  • Vaginal infections

Diflucan 150mg Generic Name & Formulations

General Description

Fluconazole 150mg; tabs.

Pharmacological Class

Azole antifungal.

How Supplied



Generic Availability


Diflucan 150mg Indications


Vaginal candidiasis.

Diflucan 150mg Dosage and Administration


150mg orally once.


Not recommended.

Diflucan 150mg Contraindications


Concomitant terfenadine at multiple doses of fluconazole ≥400mg. Concomitant drugs known to prolong the QT interval and metabolized by CYP3A4 (eg, erythromycin, pimozide, quinidine).

Diflucan 150mg Boxed Warnings

Not Applicable

Diflucan 150mg Warnings/Precautions


Risk of serious hepatotoxicity; monitor liver function during therapy and for signs/symptoms of hepatic injury; discontinue if occurs. Proarrhythmic conditions. Monitor closely for skin rashes; discontinue if lesions progress. Allergy to other azoles. Renal or hepatic impairment. Elderly. Pregnancy: avoid; may cause rare congenital anomalies in infants exposed in-utero during 1st trimester. Nursing mothers.

Diflucan 150mg Pharmacokinetics




Renal (~91%). Half-life: ~30 hours (range: 20–50 hours).

Diflucan 150mg Interactions


See Contraindications. Avoid concomitant voriconazole; if needed, monitor closely esp. when given within 24hrs after fluconazole. Caution with amiodarone (esp. with high-dose fluconazole), other drugs metabolized by CYP2C9 and CYP3A4 with a narrow therapeutic window. Potentiates abrocitinib, lemborexant; avoid. Potentiates ivacaftor, warfarin, sulfonylureas, oral midazolam, theophylline, tofacitinib, tolvaptan, triazolam, alfentanil, amitriptyline, nortriptyline, saquinavir, sirolimus, carbamazepine, NSAIDs, zidovudine; monitor and adjust dose as necessary. May increase levels of phenytoin, halofantrine, ibrutinib, methadone, rifabutin, tacrolimus, vinca alkaloids, cyclosporine, fentanyl, CCBs, losartan, lurasidone; monitor. Concomitant celecoxib: reduce celecoxib dose by half. Increased risk of myopathy/rhabdomyolysis with concomitant HMG-CoA reductase inhibitors; may need dose reduction of these statins. Avoid concomitant olaparib; reduce its dose if unavoidable. May be potentiated by diuretics. May be antagonized by oral cimetidine, rifampin. Concomitant prednisone: monitor for adrenal cortex insufficiency when fluconazole stopped. CNS effects with Vitamin A. Oral contraceptives: see full labeling. Avoid other hepatotoxic drugs.

Diflucan 150mg Adverse Reactions

Adverse Reactions

Nausea, headache, rash, vomiting, abdominal pain, diarrhea, dizziness; hepatotoxicity, adrenal insufficiency; rare: anaphylaxis, exfoliative dermatitis, QT prolongation, Torsade de pointes.

Diflucan 150mg Clinical Trials

See Literature

Diflucan 150mg Note

Not Applicable

Diflucan 150mg Patient Counseling

See Literature