• Hyperacidity, GERD, and ulcers

Dicyclomine Generic Name & Formulations

General Description

Dicyclomine HCl 10mg caps; 20mg tabs.

Pharmacological Class


How Supplied

Caps, tabs, syrup—contact supplier; Amps (2mL)—5

Dicyclomine Indications


Irritable bowel syndrome.

Dicyclomine Dosage and Administration


Initially 20mg 4 times daily; after 1 week may increase to 40mg 4 times daily if tolerated. Discontinue if not effective within 2 weeks or daily doses ≥80mg are not tolerated.


<6mos: see Contraindications. ≥6mos: consult manufacturer.

Dicyclomine Contraindications


Glaucoma. Unstable cardiovascular status. GI or urinary tract obstruction. Severe ulcerative colitis. Myasthenia gravis. Reflux esophagitis. Children <6months of age. Nursing mothers.

Dicyclomine Boxed Warnings

Not Applicable

Dicyclomine Warnings/Precautions


Inj: avoid IV administration (may cause thrombosis, inj site reactions). Autonomic neuropathy. Hepatic or renal impairment. Cardiovascular disease. Hypertension. Hyperthyroidism. Salmonella dysentery. Toxic megacolon. Ulcerative colitis. GI or GU obstruction. High environmental temperature. Diarrhea. Elderly. Debilitated. Pregnancy (Cat.B).

Dicyclomine Pharmacokinetics

See Literature

Dicyclomine Interactions


Antacids may inhibit absorption; avoid. May antagonize anti-glaucoma agents or drugs that alter GI motility (eg, metoclopramide). Antagonized by agents used to treat achlorhydria and those used to test gastric secretion. Additive anticholinergic effects with other anticholinergics, narcotic analgesics, type I antiarrhythmics, antihistamines, antipsychotics, tricyclics, amantadine, benzodiazepines, MAOIs, nitrites, nitrates, sympathomimetics. May affect absorption of sust rel dosage forms.

Dicyclomine Adverse Reactions

Adverse Reactions

Dizziness, dry mouth, blurred vision, nausea, somnolence, asthenia, and nervousness; cardiovascular and CNS symptoms (eg, psychosis, delirium). Fatal reactions have occurred in infants.

Dicyclomine Clinical Trials

See Literature

Dicyclomine Note


Formerly known under the brand name Bentyl.

Dicyclomine Patient Counseling

See Literature