Diclofenac 1.5%

  • Arthritis/rheumatic disorders

Diclofenac 1.5% Generic Name & Formulations

General Description

Diclofenac sodium 1.5%; topical soln.

Pharmacological Class

NSAID (benzeneacetic acid deriv.).

See Also

How Supplied

Soln 1.5%—contact supplier; Pump 2%—112g

Generic Availability

Soln 1.5% (YES); Pump 2% (NO)

Diclofenac 1.5% Indications


To treat signs/symptoms of osteoarthritis of the knee(s).

Diclofenac 1.5% Dosage and Administration


Use lowest effective dose for shortest duration. Apply to clean, dry skin. Initially dispense 10 drops; spread evenly around front, back and sides of the knee; repeat until 40 drops have been applied and knee is completely covered with solution. Usual dose: 40 drops/knee 4 times daily. Wash hands. Wait until area is dry before skin-to skin contact or applying other topical products (eg, sunscreen, insect repellent, lotion, moisturizer, cosmetics, medications).


Not established.

Diclofenac 1.5% Contraindications


Aspirin allergy. Coronary artery bypass graft surgery.

Diclofenac 1.5% Boxed Warnings

Boxed Warning

Risk of serious cardiovascular and gastrointestinal events.

Diclofenac 1.5% Warnings/Precautions


Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Advanced renal disease: not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, and renal function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Do not apply to open wounds, infections, inflammations, exfoliative dermatitis. Avoid eyes, mucous membranes, external heat and/or occlusive dressings, sunlight. Elderly. Debilitated. Labor & delivery. Pregnancy (avoid during ≥30 weeks gestation): increased risk of premature closure of the fetal ductus arteriosus; (20–30 weeks gestation): may cause fetal renal dysfunction/oligohydramnios; if treatment needed, limit dose and duration of use. Nursing mothers.

Diclofenac 1.5% Pharmacokinetics

See Literature

Diclofenac 1.5% Interactions


Avoid concomitant aspirin, salicylates (eg, diflunisal, salsalate) or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Caution with other hepatotoxic drugs (eg, acetaminophen, certain antibiotics, antiepileptics).

Diclofenac 1.5% Adverse Reactions

Adverse Reactions

Application site reactions (eg, dry skin, contact dermatitis, pruritus, vesicles), GI upset; cardiovascular thrombotic events, GI ulcer/bleed, edema, hepatotoxicity, renal toxicity, hypersensitivity reactions, serious skin reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis), Drug Reaction with Eosinophilia and Systemic Symptoms (discontinue if occurs), anemia.

Diclofenac 1.5% Clinical Trials

See Literature

Diclofenac 1.5% Note


Formerly known under the brand name Pennsaid.

Diclofenac 1.5% Patient Counseling

See Literature