Diclegis Generic Name & Formulations
Doxylamine succinate 10mg, pyridoxine HCl 10mg; del-rel tabs.
Antihistamine + Vit. B6 analog.
Nausea and vomiting of pregnancy in women who do not respond to conservative management.
Limitations of Use
Not studied in women with hyperemesis gravidarum.
Diclegis Dosage and Administration
Swallow whole. Take on empty stomach with water. ≥18yrs: Day 1: initially 2 tabs at bedtime; continue same dose next day if symptoms adequately controlled. If symptoms persist into afternoon of Day 2, take usual dose of 2 tabs at bedtime that night, and then starting on Day 3 take 3 tabs (1 tablet in AM and 2 tabs at bedtime); continue if symptoms adequately controlled. If symptoms persist, starting on Day 4 take 4 tabs (1 tab in the AM, 1 tab mid-afternoon, and 2 tabs at bedtime). Max 4 tabs daily.
<18yrs: not established.
Concomitant MAOIs; may prolong and intensify anticholinergic effects.
Diclegis Boxed Warnings
Asthma. Increased intraocular pressure. Narrow angle glaucoma. Stenosing peptic ulcer. Pyloroduodenal obstruction. Urinary bladder-neck obstruction. Reevaluate as pregnancy progresses. Nursing mothers: not recommended.
See Contraindications. Concomitant alcohol, other CNS depressants (eg, hypnotic sedatives, tranquilizers): not recommended. Concomitant food may delay onset of action and reduce absorption. May cause false (+) urine test for methadone, opiates, PCP.
Diclegis Adverse Reactions
Diclegis Clinical Trials
Diclegis Patient Counseling