Dibenzyline Generic Name & Formulations
Phenoxybenzamine HCl 10mg; caps.
Alpha adrenergic blocker.
Treatment of pheochromocytoma, to control episodes of hypertension and sweating. May use concomitant β-blocker if tachycardia is excessive.
Dibenzyline Dosage and Administration
Individualize. Initially 10mg twice daily. Increase dose every other day, usually to 20–40mg 2 or 3 times daily, until optimal dose obtained. Observe patients after each increase before instituting another increase.
Conditions where a fall in BP may be undesirable.
Dibenzyline Boxed Warnings
Cerebral or coronary arteriosclerosis. Renal damage. May aggravate respiratory infections. Pregnancy (Cat.C). Nursing mothers: not recommended.
Concomitant drugs that stimulate both alpha- and beta-adrenergic receptors (eg, epinephrine) may produce exaggerated hypotensive response and tachycardia. Blocks hyperthermia production by levarterenol. Blocks hypothermia production by reserpine.
Dibenzyline Adverse Reactions
Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis, GI upset, drowsiness, fatigue. May be carcinogenic (w. long-term use: not recommended).
Dibenzyline Clinical Trials
Dibenzyline Patient Counseling