• Parkinsonism

Dhivy Generic Name & Formulations

General Description

Carbidopa, levodopa 25mg/100mg; functionally scored tabs.

Pharmacological Class

Dopa-decarboxylase inhibitor + dopamine precursor.

How Supplied


Generic Availability


Dhivy Indications


Treatment of Parkinson’s disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.

Dhivy Dosage and Administration


Individualize. Initially one tab (25mg/100mg) 3 times daily; may increase by up to one whole tab every day or every other day as needed; max 8 whole tabs daily.


Not established.

Dhivy Contraindications


During or within 14 days of nonselective MAOIs (eg, phenelzine, linezolid, tranylcypromine).

Dhivy Boxed Warnings

Boxed Warning

Dhivy Warnings/Precautions


Sleep disorders; consider discontinuing if significant daytime sleepiness occurs. History of MI with residual arrhythmias; monitor cardiac function. Risk of hallucinations and psychosis. Major psychotic disorder: not recommended. Depression. Suicidal tendencies. Impulse control/compulsive behaviors; consider dose reduction or discontinuation if develops. Peptic ulcer. Glaucoma; monitor IOP. Withdrawal-emergent hyperpyrexia or confusion: avoid sudden discontinuation or rapid dose reduction. Pregnancy. Nursing mothers.

Dhivy Pharmacokinetics

See Literature

Dhivy Interactions


See Contraindications. Concomitant dopamine-depleting agents (eg, reserpine, tetrabenazine) or other drugs known to deplete monoamine stores: not recommended. Antagonized by dopamine D2 receptor antagonists (eg, phenothiazines, butyrophenones, risperidone, metoclopramide), isoniazid, iron salts. Delayed absorption with high-protein diet, high-fat, high-calorie meals or excessive acidity. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.

Dhivy Adverse Reactions

Adverse Reactions

Dyskinesias (eg, choreiform, dystonic), other involuntary movements, nausea; cardiovascular ischemic events, lab abnormalities.

Dhivy Clinical Trials

See Literature

Dhivy Note

Not Applicable

Dhivy Patient Counseling

See Literature