Dexamethasone Oral Solution

  • Corticosteroid-responsive disorders

Dexamethasone Oral Solution Generic Name & Formulations

General Description

Dexamethasone 0.5mg/5mL.

Pharmacological Class


How Supplied

Soln—240mL, 500mL; Intensol—30mL (w. dropper)


Dexamethasone Oral Solution Indications


Corticosteroid-responsive disorders.

Dexamethasone Oral Solution Dosage and Administration


See full labeling. Initally 0.75–9mg daily. Intensol: mix with liquid or semi-solid food.


See full labeling. Initally 0.02–0.3mg/kg/day in 3–4 divided doses. Intensol: mix with liquid or semi-solid food.

Dexamethasone Oral Solution Contraindications


Systemic fungal infection. Live vaccination.

Dexamethasone Oral Solution Boxed Warnings

Not Applicable

Dexamethasone Oral Solution Warnings/Precautions


Cerebral malaria, optic neuritis, active ocular herpes simplex: not recommended. Strongyloides infestation. Tuberculosis. Latent or active amebiasis. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Recent MI. CHF. Hypertension. Renal insufficiency. Peptic ulcers. Diverticulitis. Intestinal anastomoses. Ulcerative colitis. Cirrhosis. Postmenopausal women (osteoporosis risk). Diabetes. Thyroid disorder. Myasthenia gravis. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Monitor thyroid, weight, growth, fluid, electrolyte balance and intraocular pressure (w. therapy >6wks). Pregnancy (Cat.C). Nursing mothers: not recommended.

Dexamethasone Oral Solution Pharmacokinetics

See Literature

Dexamethasone Oral Solution Interactions


Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), ephedrine. May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Increased GI effects with aspirin or other NSAIDs. Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Toxic epidermal necrolysis possible with thalidomide. Concomitant indomethacin: may get false-negative on dexamethasone suppression test. May suppress reactions to skin tests.

Dexamethasone Oral Solution Adverse Reactions

Adverse Reactions

HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, hyperglycemia.

Dexamethasone Oral Solution Clinical Trials

See Literature

Dexamethasone Oral Solution Note

Not Applicable

Dexamethasone Oral Solution Patient Counseling

See Literature