Detrol Generic Name & Formulations
Tolterodine tartrate 1mg, 2mg; tabs.
LA—30, 90, 500; Tabs—60, 500
Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.
Detrol Dosage and Administration
2mg twice daily; may decrease to 1mg twice daily. Concomitant strong CYP3A4 inhibitors (ketoconazole, itraconazole, miconazole, clarithromycin, erythromycin, cyclosporine, vinblastine), or significant renal or hepatic dysfunction: 1mg twice daily.
Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.
Detrol Boxed Warnings
Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.
Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.
Detrol Adverse Reactions
Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.
Detrol Clinical Trials
Detrol Patient Counseling