Detrol La

  • Overactive bladder/enuresis

Detrol La Generic Name & Formulations

General Description

Tolterodine tartrate 2mg, 4mg; ext-rel caps.

Pharmacological Class

Muscarinic antagonist.

See Also

How Supplied

LA—30, 90, 500; Tabs—60, 500


Generic Availability


Detrol La Indications


Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.

Detrol La Dosage and Administration


Swallow whole. 4mg once daily; may decrease to 2mg once daily. Concomitant strong CYP3A4 inhibitors (eg, ketoconazole, clarithromycin, ritonavir), or severe renal or mild to moderate hepatic dysfunction: 2mg once daily. Severe hepatic impairment, CrCl<10mL/min: not recommended.


Not established.

Detrol La Contraindications


Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.

Detrol La Boxed Warnings

Not Applicable

Detrol La Warnings/Precautions


Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.

Detrol La Pharmacokinetics

See Literature

Detrol La Interactions


Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.

Detrol La Adverse Reactions

Adverse Reactions

Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.

Detrol La Clinical Trials

See Literature

Detrol La Note

Not Applicable

Detrol La Patient Counseling

See Literature