Detrol La Generic Name & Formulations
Tolterodine tartrate 2mg, 4mg; ext-rel caps.
LA—30, 90, 500; Tabs—60, 500
Detrol La Indications
Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.
Detrol La Dosage and Administration
Swallow whole. 4mg once daily; may decrease to 2mg once daily. Concomitant strong CYP3A4 inhibitors (eg, ketoconazole, clarithromycin, ritonavir), or severe renal or mild to moderate hepatic dysfunction: 2mg once daily. Severe hepatic impairment, CrCl<10mL/min: not recommended.
Detrol La Contraindications
Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.
Detrol La Boxed Warnings
Detrol La Warnings/Precautions
Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.
Detrol La Pharmacokinetics
Detrol La Interactions
Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.
Detrol La Adverse Reactions
Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.
Detrol La Clinical Trials
Detrol La Note
Detrol La Patient Counseling