• Poisoning/overdose

Desferal Generic Name & Formulations

General Description

Deferoxamine mesylate 250mg/mL; for inj after reconstitution.

Pharmacological Class

Iron chelating agent.

How Supplied

Vials 500mg—4

Desferal Indications


Acute iron intoxication. Chronic iron overload due to multiple transfusions.

Desferal Dosage and Administration

Adults and Children

Routes other than IM: see literature. <3yrs: not recommended. ≥3yrs: acute iron toxicity: 1g IM initially followed by 500mg every 4 hours for 2 doses; repeat every 4–12 hours if needed; max 6g/day. Chronic iron overload: see literature.

Desferal Contraindications


Severe renal disease. Anuria.

Desferal Boxed Warnings

Not Applicable

Desferal Warnings/Precautions


Ocular or auditory disturbances. Perform visual acuity tests, slit-lamp exams, funduscopy and audiometry with prolonged therapy. High doses in patients with low ferritin levels may retard growth. Acute respiratory distress syndrome with high IV doses. Flushing, urticaria, hypotension, and shock if given rapid IV. Monitor changes in renal function. Discoloration of urine. Elderly. Pregnancy (Cat.C). Nursing mothers.

Desferal Pharmacokinetics

See Literature

Desferal Interactions


Possible impairment of cardiac function with concomitant high dose Vit. C; give max adult dose: 200mg in divided doses. May cause temporary impairment of consciousness with prochlorperazine.

Desferal Adverse Reactions

Adverse Reactions

Localized skin reactions, hypersensitivity, tachycardia, hypotension, shock, dysuria, leg cramps, fever, GI upset; increased serum creatinine, acute renal failure, renal tubular disorder; rare: Yersinia infections, mucormycosis.

Desferal Clinical Trials

See Literature

Desferal Note

Not Applicable

Desferal Patient Counseling

See Literature