• Hypogonadism

Depo-testosterone Generic Name & Formulations

General Description

Testosterone cypionate 100mg/mL, 200mg/mL; IM inj in cottonseed oil; contains benzyl alcohol.

Pharmacological Class


How Supplied

Vial 100mg/mL (10mL)—1; 200mg/mL (1mL, 10mL)—1


Depo-testosterone Indications


Testosterone replacement therapy.

Limitations of Use

Not established in men with age-related hypogonadism.

Depo-testosterone Dosage and Administration


Prior to treatment, confirm diagnosis by ensuring serum testosterone is below normal range as measured in the AM on at least 2 separate days. Give by deep IM inj into gluteal muscle once every 2 to 4 weeks. 50–400mg; max 400mg/month.


<12yrs: Not established.

Depo-testosterone Contraindications


Serious cardiac, hepatic, or renal disease. Male breast or prostate cancer. Use in women. Pregnancy (Cat.X).

Depo-testosterone Boxed Warnings

Not Applicable

Depo-testosterone Warnings/Precautions


Discontinue if jaundice, abnormal liver function, hypercalcemia, or edema occurs. Monitor liver function, hemoglobin, hematocrit, prostate specific antigen (PSA), cholesterol, bone age. Cardiac, hepatic, or renal dysfunction. May increase risk of prostatic hyperplasia in elderly. May increase growth of subclinical prostatic carcinoma. Monitor for venous thromboembolism; discontinue if suspected. Inform patients of possible increased risk of MI, stroke. Elderly. Young children. Nursing mothers: not recommended.

Depo-testosterone Pharmacokinetics

See Literature

Depo-testosterone Interactions


May potentiate oral anticoagulants, oxyphenbutazone. May alter insulin effects. Increased risk of edema with ACTH, corticosteroids.

Depo-testosterone Adverse Reactions

Adverse Reactions

Inj site reactions, peliosis hepatis, premature epiphyseal closure in adolescents, edema, hepatic carcinoma, prostatic hypertrophy or carcinoma, gynecomastia, priapism, oligospermia, nausea, jaundice, hirsutism, virilization, male pattern baldness, acne, polycythemia, headache, anxiety, depression, paresthesias, altered libido, fluid and electrolyte disturbances, suppression of clotting factors, increased serum cholesterol.

Depo-testosterone Clinical Trials

See Literature

Depo-testosterone Note

Not Applicable

Depo-testosterone Patient Counseling

See Literature