Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Dengvaxia Generic Name & Formulations
Legal Class
Rx
General Description
Dengue tetravalent vaccine, live; susp for SC inj after reconstitution (contains 4.5–6.0 log10CCID50 of each chimeric yellow fever dengue (CYD) virus serotypes 1, 2, 3, 4); per 0.5mL; preservative-free.
How Supplied
Single-dose vial—1 (w. diluent)
Manufacturer
Generic Availability
NO
Dengvaxia Indications
Indications
Immunization against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4 in individuals 9–16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas.
Limitations of Use
Not for use if not previously infected by any dengue virus serotype or for whom this information is unknown. Safety and efficacy have not been established in individuals living in dengue non-endemic areas who travel to dengue endemic areas.
Dengvaxia Dosage and Administration
Adult
>16yrs: not established.
Children
<9yrs: not established. Give by SC inj only. ≥9yrs to ≤16yrs: one 0.5mL dose at month 0, 6, and 12.
Dengvaxia Contraindications
Contraindications
Severe immunodeficiency or immunosuppression due to disease or therapy.
Dengvaxia Boxed Warnings
Not Applicable
Dengvaxia Warnings/Precautions
Warnings/Precautions
Increased risk of severe dengue infection following Dengvaxia if not previously infected by dengue virus. Evaluate for prior dengue infection; avoid vaccination if not previously infected or unknown. Have appropriate medical treatment and supervision available to manage allergic reactions. Limitations of vaccine effectiveness; advise to continue personal protection measures against mosquito bites after vaccination. Labor & delivery. Pregnancy. Nursing mothers.
Dengvaxia Pharmacokinetics
See Literature
Dengvaxia Interactions
Interactions
Immunosuppressants (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, high-dose steroids) may reduce immune response to Dengvaxia. May cause false (–) results of tuberculin purified protein derivative (PPD) test sensitivity; give tuberculin test before or ≥1month after Dengvaxia vaccine.
Dengvaxia Adverse Reactions
Adverse Reactions
Headache, inj site pain, malaise, asthenia, myalgia; hypersensitivity reactions, syncope.
Dengvaxia Clinical Trials
See Literature
Dengvaxia Note
Not Applicable
Dengvaxia Patient Counseling
See Literature
Images
