• Hypertension

Demser Generic Name & Formulations

General Description

Metyrosine 250mg; caps.

Pharmacological Class

Tyrosine hydroxylase inhibitor.

How Supplied


Demser Indications


Treatment of pheochromocytoma for: preoperative preparation for surgery; or management when surgery is contraindicated. Chronic treatment in malignant pheochromocytoma.

Demser Dosage and Administration


Initially 250mg 4 times daily; may increase by 250–500mg daily up to max 4g/day in divided doses. Usual dose: 2–3g/day; monitor. If hypertensive, titrate dose to normalize BP and control symptoms; if normotensive, titrate dose to reduce urinary metanephrines and/or vanillylmandelic acid by ≥50%. Add an α-blocker (eg, phenoxybenzamine) if patients not adequately controlled. Pre-op prep: treat for at least 5–7 days.


Not recommended.

Demser Contraindications

Not Applicable

Demser Boxed Warnings

Not Applicable

Demser Warnings/Precautions


Renal or hepatic impairment. Maintain adequate hydration; if crystalluria occurs, increase more fluids; if crystalluria persists, reduce dose or discontinue. Pre-op use: maintain adequate intravascular volume intra- and postoperatively. Pregnancy (Cat.C). Nursing mothers.

Demser Pharmacokinetics

See Literature

Demser Interactions


Increased CNS effects with alcohol, other CNS depressants (eg, hypnotics, sedatives, tranquilizers). Potentiates extrapyramidal effects of phenothiazines, haloperidol.

Demser Adverse Reactions

Adverse Reactions

Sedation, diarrhea, extrapyramidal effects, anxiety, CNS disturbances, crystalluria; rare: hematological disorders.

Demser Clinical Trials

See Literature

Demser Note

Not Applicable

Demser Patient Counseling

See Literature