Demeclocycline Hcl

  • Bacterial infections

Demeclocycline Hcl Generic Name & Formulations

General Description

Demeclocycline HCl 150mg, 300mg; tabs.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Contact supplier.

Demeclocycline Hcl Indications


Tetracycline-sensitive infections, including respiratory, genitourinary, skin and skin structure, soft tissues, and those caused by rickettsiae and Mycoplasma pneumoniae; also cholera, psittacosis, plague, shigellosis.

Demeclocycline Hcl Dosage and Administration


Take with fluids, 1hr before or 2hrs after meals. 150mg 4 times daily or 300mg twice daily. Gonorrhea patients sensitive to penicillin: initially 600mg followed by 300mg every 12hrs for 4 days to a total of 3g.


<8yrs: not recommended. Take with fluids, 1hr before or 2hrs after meals. ≥8yrs: 7–13mg/kg/day divided into 2–4 doses; max 600mg/day.

Demeclocycline Hcl Contraindications

Not Applicable

Demeclocycline Hcl Boxed Warnings

Not Applicable

Demeclocycline Hcl Warnings/Precautions


Renal or hepatic impairment. Monitor blood, renal and hepatic function in long-term use. Avoid sun and UV light. Discontinue if skin erythema occurs. Pregnancy (Cat.D), nursing mothers: not recommended.

Demeclocycline Hcl Pharmacokinetics

See Literature

Demeclocycline Hcl Interactions


Avoid methoxyflurane, photosensitizing agents. May antagonize bactericidal antibiotics; avoid. Reduced absorption with antacids, iron, zinc, calcium, magnesium, dairy products, urinary alkalinizers, other multivalent cations. May reduce effectiveness of oral contraceptives. Monitor prothrombin time with oral anticoagulants.

Demeclocycline Hcl Adverse Reactions

Adverse Reactions

Photosensitivity, GI upset, rash, blood dyscrasias, increased BUN, hepatotoxicity, C. difficile associated diarrhea, pseudotumor cerebri; rare: esophagitis and esophageal ulceration.

Demeclocycline Hcl Clinical Trials

See Literature

Demeclocycline Hcl Note


Formerly known under the brand name Declomycin.

Demeclocycline Hcl Patient Counseling

See Literature