Bacterial infections:

Indications for: Demeclocycline HCl

Tetracycline-sensitive infections, including respiratory, genitourinary, skin and skin structure, soft tissues, and those caused by rickettsiae and Mycoplasma pneumoniae; also cholera, psittacosis, plague, shigellosis.

Adult Dosage:

Take with fluids, 1hr before or 2hrs after meals. 150mg 4 times daily or 300mg twice daily. Gonorrhea patients sensitive to penicillin: initially 600mg followed by 300mg every 12hrs for 4 days to a total of 3g.

Children Dosage:

<8yrs: not recommended. Take with fluids, 1hr before or 2hrs after meals. ≥8yrs: 7–13mg/kg/day divided into 2–4 doses; max 600mg/day.

Demeclocycline HCl Warnings/Precautions:

Renal or hepatic impairment. Monitor blood, renal and hepatic function in long-term use. Avoid sun and UV light. Discontinue if skin erythema occurs. Pregnancy (Cat.D), nursing mothers: not recommended.

Demeclocycline HCl Classification:

Tetracycline antibiotic.

Demeclocycline HCl Interactions:

Avoid methoxyflurane, photosensitizing agents. May antagonize bactericidal antibiotics; avoid. Reduced absorption with antacids, iron, zinc, calcium, magnesium, dairy products, urinary alkalinizers, other multivalent cations. May reduce effectiveness of oral contraceptives. Monitor prothrombin time with oral anticoagulants.

Adverse Reactions:

Photosensitivity, GI upset, rash, blood dyscrasias, increased BUN, hepatotoxicity, C. difficile associated diarrhea, pseudotumor cerebri; rare: esophagitis and esophageal ulceration.


Formerly known under the brand name Declomycin.

How Supplied:

Contact supplier.