• Miscellaneous urogenital disorders

Deflux Generic Name & Formulations

General Description

Dextranomer microspheres 50mg/mL viscous gel in stabilized hyaluronic acid 15mg/mL carrier gel; implant for submucosal inj.

How Supplied

Single-use syringe (1mL)—1

Deflux Indications


Vesicoureteral reflux (VUR) grades II–IV in children.

Deflux Dosage and Administration


Not applicable.


<1yr: not recommended. ≥1yr: see literature. Must use Deflux metal needle for administration. Inject submucosally in urinary bladder near the ureteral orifice.

Deflux Contraindications


Non-functional kidney. Hutch diverticulum. Ureterocele. Active voiding dysfunction. Ongoing UTI.

Deflux Boxed Warnings

Not Applicable

Deflux Warnings/Precautions


Do not inject intravascularly. Must be administered by qualified surgeon experienced in the use of cystoscope and trained in subureteric injection procedures. Use of >6mL (3mL at each ureteral orifice) at same treatment session: not recommended. Treatment of duplex systems has not been studied. Ureters with grossly dilated orifices. Infection and bleeding risks associated with cystoscopic procedure.

Deflux Pharmacokinetics

See Literature

Deflux Interactions

Not Applicable

Deflux Adverse Reactions

Adverse Reactions

UTI, ureteral dilatation, nausea, vomiting, abdominal pain.

Deflux Clinical Trials

See Literature

Deflux Note

Not Applicable

Deflux Patient Counseling

See Literature