• Muscle spasms

Dantrium Generic Name & Formulations

General Description

Dantrolene sodium 25mg, 50mg, 100mg; caps.

Pharmacological Class

Muscle relaxant (local).

How Supplied


Generic Availability


Dantrium Indications


Chronic spasticity due to upper motor neuron disorders (eg, spinal cord injury, stroke, cerebral palsy, multiple sclerosis).

Dantrium Dosage and Administration


Use lowest effective dose. 25mg once daily for 7 days, then 25mg 3 times daily for 7 days, then 50mg 3 times daily for 7 days, then 100mg 3 times daily; max 100mg 4 times daily.


<5yrs: not established. ≥5yrs: Use lowest effective dose. 0.5mg/kg once daily for 7 days, then 0.5mg/kg 3 times daily for 7 days, then 1mg/kg 3 times daily for 7 days, then 2mg/kg 3 times daily; max 100mg 4 times daily.

Dantrium Contraindications


Active hepatic disease. Spasticity utilization to sustain upright posture/balance in locomotion or to obtain increased function.

Dantrium Boxed Warnings

Boxed Warning


Dantrium Warnings/Precautions


Risk of hepatotoxicity (esp. females or patients >35 years, or concomitant other drugs); monitor liver function at baseline and during therapy; discontinue if hepatitis or liver abnormalities develop. History of liver disease. Pulmonary dysfunction. Severely impaired cardiac function. Discontinue if no improvement after 45 days of treatment. Avoid exposure to sunlight. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Dantrium Pharmacokinetics

See Literature

Dantrium Interactions


Estrogens may increase risk of hepatotoxicity. Potentiates CNS depressants (eg, sedatives, tranquilizers). Avoid concurrent verapamil (cardiovascular collapse). May potentiate vecuronium.

Dantrium Adverse Reactions

Adverse Reactions

Drowsiness, dizziness, weakness, fatigue, diarrhea, urinary changes, tachycardia, seizures, depression; hepatotoxicity, hepatitis, photosensitivity, pleural effusion with associated eosinophilia.

Dantrium Clinical Trials

See Literature

Dantrium Note

Not Applicable

Dantrium Patient Counseling

See Literature