Cytovene Iv Generic Name & Formulations
Ganciclovir sodium 500mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution.
Cytovene Iv Indications
Treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including those with AIDS. Prevention of CMV disease in high-risk transplant recipients.
Cytovene Iv Dosage and Administration
Give by IV infusion over 1 hour. Induction for CMV retinitis: 5mg/kg every 12 hours for 14–21 days. Maintenance: 5mg/kg once daily for 7 days per week or 6mg/kg once daily for 5 days per week. Prevention of CMV (transplant): 5mg/kg every 12 hours for 7–14 days, then 5mg/kg once daily for 7 days per week or 6mg/kg once daily for 5 days per week. Renal impairment, hemodialysis: adjust or reduce dose; see full labeling.
Cytovene Iv Contraindications
Cytovene Iv Boxed Warnings
Hematologic toxicity. Impairment of fertility. Fetal toxicity. Mutagenesis and carcinogenesis.
Cytovene Iv Warnings/Precautions
Risk of hematologic toxicity; monitor CBCs and platelets frequently esp. in patients with renal dysfunction, history of leukopenia with ganciclovir or other nucleoside analogues, baseline ANC <1000cells/microliter. ANC <500cells/microliter, hemoglobin <8g/dL, platelets <25,000cells/microliter: not recommended. Pre-existing cytopenias or history of cytopenic reactions to other drugs, chemicals, or irradiation. Potential to cause impairment of fertility, fetal toxicity, cancer. Renal impairment. Monitor ophthalmic and renal function. Maintain adequate hydration. Avoid contact with skin, mucous membranes. Pregnancy: exclude status prior to initiation. Use effective contraception during and for at least 30 days (females) or 90 days (males) after treatment. Nursing mothers: not recommended.
Cytovene Iv Pharmacokinetics
Cytovene Iv Interactions
Avoid imipenem-cilastatin (seizures). Monitor renal function with concomitant cyclosporine, amphotericin B. Caution with myelosuppressive or other nephrotoxic drugs (eg, dapsone, doxorubicin, flucytosine, hydroxyurea, pentamidine, tacrolimus, trimethoprim/sulfamethoxazole, vinblastine, vincristine, zidovudine). Monitor for toxicity with didanosine, mycophenolate mofetil. May be potentiated by probenecid.
Cytovene Iv Adverse Reactions
Pyrexia, diarrhea, leukopenia, nausea, anemia, asthenia, headache, cough, decreased appetite, dyspnea, abdominal pain, sepsis, hyperhidrosis, blood creatinine increased, thrombocytopenia; retinal detachment.
Cytovene Iv Clinical Trials
Cytovene Iv Note
Cytovene Iv Patient Counseling