• Miscellaneous urogenital disorders

Cystagon Generic Name & Formulations

General Description

Cysteamine bitartrate 50mg, 150mg; caps.

Pharmacological Class

Cystine-depleting agent.

How Supplied



Cystagon Indications


Management of nephropathic cystinosis.

Cystagon Dosage and Administration


New patients: start on ¼ to ⅙ of the maintenance dose; increase gradually over 4–6 weeks. Maintenance: >12yrs and >110lbs: 2g/day divided 4 times daily. Max 1.95g/m2/day. Goal of therapy to keep leukocyte cystine levels below 1nmol/½ cystine/mg protein 5–6 hours after administration. Patients taking cysteamine HCl or phosphocysteamine solutions may be transferred to equimolar doses of cysteamine bitartrate.


1.3g/m2/day in 4 divided doses. Max 1.95g/m2/day. If <6yrs old: do not give intact caps; may open and sprinkle capsule contents over food.

Cystagon Contraindications


Penicillamine hypersensitivity.

Cystagon Boxed Warnings

Not Applicable

Cystagon Warnings/Precautions


Withhold dose if skin rash develops, may be restarted at a lower dose then titrated slowly; if severe, do not readminister. Monitor blood counts, LFTs, vision, skin, bones. Measure leukocyte cystine levels every 3 months, more frequently when transferring from cysteamine HCl or phosphocysteamine solutions. Pregnancy (Cat.C). Nursing mothers: not recommended.

Cystagon Pharmacokinetics

See Literature

Cystagon Interactions

Not Applicable

Cystagon Adverse Reactions

Adverse Reactions

Vomiting, anorexia, fever, diarrhea, lethargy, rash; skin or bone lesions (reduce dose if appears), leukopenia, abnormal LFTs, CNS effects, GI ulceration/bleeding, pseudotumor cerebri, papilledema; rare: interstitial nephritis with early renal failure.

Cystagon Clinical Trials

See Literature

Cystagon Note

Not Applicable

Cystagon Patient Counseling

See Literature