Cystadane Generic Name & Formulations
Betaine anhydrous 1g; per scoopful; pwd for oral soln after reconstitution.
Bottle—180g (w. measuring scoop)
Treatment of homocystinuria (eg, cystathionine beta-synthase [CBS] deficiency, 5,10-methylenetetrahydrofolate reductase [MTHFR] deficiency, cobalamin cofactor metabolism [cbl] defect) to decrease elevated homocysteine blood levels.
Cystadane Dosage and Administration
Adults and Children
Dissolve one scoop (1g betaine anhydrous pwd) in 4–6 ounces of water, juice, milk, formula, or mixed with food for immediate ingestion. <3yrs: initially 100mg/kg/day divided in twice daily doses, may increase weekly by 50mg/kg increments. ≥3yrs: 3g twice daily. Increase gradually until plasma total homocysteine is undetectable or present only in small amounts. Up to 20g/day has been used.
Cystadane Boxed Warnings
Hypermethioninemia. Monitor plasma methionine concentrations in patients with CBS deficiency. Pregnancy. Nursing mothers.
Cystadane Adverse Reactions
Nausea, GI distress; hypermethioninemia, cerebral edema.
Cystadane Clinical Trials
Cystadane Patient Counseling