Cymbalta Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Cymbalta Indications
Indications
Cymbalta Dosage and Administration
Adult
Children
Elderly
Start at 30mg once daily for 2 weeks before considering an increase to the target dose of 60mg/day. If increasing beyond 60mg/day, increase in increments of 30mg once daily. Max dose studied: 120mg/day.
Renal Impairment
Mild to moderate impairment: PK analysis suggests no significant effect on duloxetine clearance.
Limited data available on the effect of Cymbalta in patients with ESRD.
Hepatic Impairment
Patients with clinically evidence hepatic impairment have decreased duloxetine metabolism and elimination.
Administration
Swallow whole; do not crush or chew. Do not open the capsules and sprinkle the contents on food or liquids as these actions may affect the enteric coating.
Missed dose: Take as soon as remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Cymbalta Contraindications
Contraindications
Cymbalta Boxed Warnings
Boxed Warning
Cymbalta Warnings/Precautions
Warnings/Precautions
Cymbalta Pharmacokinetics
Absorption
Max plasma concentrations of duloxetine occur 6 hours post dose.
Distribution
Duloxetine is highly protein bound (>90%).
Elimination
Cymbalta Interactions
Interactions
Cymbalta Adverse Reactions
Adverse Reactions
Cymbalta Clinical Trials
Cymbalta Note
Not Applicable
Cymbalta Patient Counseling
Cymbalta Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Cymbalta Indications
Indications
Cymbalta Dosage and Administration
Adult
Children
Renal Impairment
Mild to moderate impairment: PK analysis suggests no significant effect on duloxetine clearance.
Limited data available on the effect of Cymbalta in patients with ESRD.
Hepatic Impairment
Patients with clinically evidence hepatic impairment have decreased duloxetine metabolism and elimination.
Administration
Swallow whole; do not crush or chew. Do not open the capsules and sprinkle the contents on food or liquids as these actions may affect the enteric coating.
Missed dose: Take as soon as remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Cymbalta Contraindications
Contraindications
Cymbalta Boxed Warnings
Boxed Warning
Cymbalta Warnings/Precautions
Warnings/Precautions
Cymbalta Pharmacokinetics
Absorption
Max plasma concentrations of duloxetine occur 6 hours post dose.
Distribution
Duloxetine is highly protein bound (>90%).
Elimination
Cymbalta Interactions
Interactions
Cymbalta Adverse Reactions
Adverse Reactions
Cymbalta Clinical Trials
Cymbalta Note
Not Applicable
Cymbalta Patient Counseling
Cymbalta Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Cymbalta Indications
Indications
Cymbalta Dosage and Administration
Adult
Children
Renal Impairment
Mild to moderate impairment: PK analysis suggests no significant effect on duloxetine clearance.
Limited data available on the effect of Cymbalta in patients with ESRD.
Hepatic Impairment
Patients with clinically evidence hepatic impairment have decreased duloxetine metabolism and elimination.
Administration
Swallow whole; do not crush or chew. Do not open the capsules and sprinkle the contents on food or liquids as these actions may affect the enteric coating.
Missed dose: Take as soon as remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Cymbalta Contraindications
Contraindications
Cymbalta Boxed Warnings
Boxed Warning
Cymbalta Warnings/Precautions
Warnings/Precautions
Cymbalta Pharmacokinetics
Absorption
Max plasma concentrations of duloxetine occur 6 hours post dose.
Distribution
Duloxetine is highly protein bound (>90%).
Elimination
Cymbalta Interactions
Interactions
Cymbalta Adverse Reactions
Adverse Reactions
Cymbalta Clinical Trials
Cymbalta Note
Not Applicable
Cymbalta Patient Counseling
Cymbalta Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Cymbalta Indications
Indications
Cymbalta Dosage and Administration
Adult
Children
Renal Impairment
Mild to moderate impairment: PK analysis suggests no significant effect on duloxetine clearance.
Limited data available on the effect of Cymbalta in patients with ESRD.
Hepatic Impairment
Patients with clinically evidence hepatic impairment have decreased duloxetine metabolism and elimination.
Administration
Swallow whole; do not crush or chew. Do not open the capsules and sprinkle the contents on food or liquids as these actions may affect the enteric coating.
Missed dose: Take as soon as remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Cymbalta Contraindications
Contraindications
Cymbalta Boxed Warnings
Boxed Warning
Cymbalta Warnings/Precautions
Warnings/Precautions
Cymbalta Pharmacokinetics
Absorption
Max plasma concentrations of duloxetine occur 6 hours post dose.
Distribution
Duloxetine is highly protein bound (>90%).
Elimination
Cymbalta Interactions
Interactions
Cymbalta Adverse Reactions
Adverse Reactions
Cymbalta Clinical Trials
Cymbalta Note
Not Applicable
Cymbalta Patient Counseling
Cymbalta Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Cymbalta Indications
Indications
Cymbalta Dosage and Administration
Adult
Children
Renal Impairment
Mild to moderate impairment: PK analysis suggests no significant effect on duloxetine clearance.
Limited data available on the effect of Cymbalta in patients with ESRD.
Hepatic Impairment
Patients with clinically evidence hepatic impairment have decreased duloxetine metabolism and elimination.
Administration
Swallow whole; do not crush or chew. Do not open the capsules and sprinkle the contents on food or liquids as these actions may affect the enteric coating.
Missed dose: Take as soon as remembered. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Cymbalta Contraindications
Contraindications
Cymbalta Boxed Warnings
Boxed Warning
Cymbalta Warnings/Precautions
Warnings/Precautions
Cymbalta Pharmacokinetics
Absorption
Max plasma concentrations of duloxetine occur 6 hours post dose.
Distribution
Duloxetine is highly protein bound (>90%).
Elimination
Cymbalta Interactions
Interactions
Cymbalta Adverse Reactions
Adverse Reactions
Cymbalta Clinical Trials
Cymbalta Note
Not Applicable
Cymbalta Patient Counseling
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