Cyanocobalamin Injection

  • Anemias

Cyanocobalamin Injection Generic Name & Formulations

General Description

Cyanocobalamin 1000mcg/mL; soln for IM or SC inj; contains benzyl alcohol.

Pharmacological Class


How Supplied

Contact supplier.

Cyanocobalamin Injection Indications


Vit. B12 deficiencies due to malabsorption. Pernicious anemia. Vit. B12 absorption test (Schilling test).

Cyanocobalamin Injection Dosage and Administration


Give by IM or deep SC inj. Pernicious anemia: 100mcg daily for 6–7 days; then 100mcg every other day for 7 doses; then every 3–4 days for 2–3 weeks; then 100mcg monthly for life. Deficiencies due to malabsorption: if severe, may need to treat like pernicious anemia; use oral preparations for chronic treatment. Schilling test: 1000mcg.


See literature.

Cyanocobalamin Injection Contraindications


Sensitivity to cobalt.

Cyanocobalamin Injection Boxed Warnings

Not Applicable

Cyanocobalamin Injection Warnings/Precautions


Hereditary optic nerve atrophy (Leber's disease). Severe megaloblastic anemia (intense treatment may lead to hypokalemia and death). Monitor potassium for first 48 hours; replace if needed. Obtain hematocrit, reticulocyte count, Vit. B12, folate, and iron levels before and during treatment. Reevaluate periodically. Premature infants. Renal impairment (possible aluminum toxicity). Folic acid use may mask B12 deficiency. Pregnancy (Cat. C).

Cyanocobalamin Injection Pharmacokinetics

See Literature

Cyanocobalamin Injection Interactions


Antibiotics, methotrexate, pyrimethamine interfere with Vit. B12 diagnostic tests. Colchicine, para-aminosalicylic acid, heavy alcohol intake for >2 weeks may produce malabsorption of Vit. B12.

Cyanocobalamin Injection Adverse Reactions

Adverse Reactions

Pulmonary edema, CHF, vascular thrombosis, polycythemia vera, transient diarrhea, itching, transitory exanthema; anaphylactic shock (may be fatal; do test dose if hypersensitivity suspected).

Cyanocobalamin Injection Clinical Trials

See Literature

Cyanocobalamin Injection Note


Formerly known under the brand names Berubigen, Cobavite, Rubivite, Rubramin PC, Vi-twel.

Cyanocobalamin Injection Patient Counseling

See Literature