Indications for COSOPT PF:
Open-angle glaucoma or ocular hypertension where β-blocker alone is inadequate.
Adults and Children:
<2yrs: not recommended. 1 drop twice daily.
COSOPT PF Contraindications:
Asthma or history of asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock.
COSOPT PF Warnings/Precautions:
Mild-to-moderate COPD or bronchospastic disease, or severe renal impairment: not recommended. Hepatic impairment. Surgery. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Discontinue if ocular effects occur. Soft contact lenses (remove, may reinsert 15 minutes after instillation). Discontinue at 1st sign of cardiac failure. Pregnancy (Cat.C). Nursing mothers: not recommended.
COSOPT PF Classification:
Carbonic anhydrase inhibitor (sulfonamide) + noncardioselective beta-blocker.
COSOPT PF Interactions:
Concomitant oral carbonic anhydrase inhibitors or other topical β-blockers: not recommended. May potentiate systemic β-blockers, reserpine, hypoglycemic agents, and mydriatic effects of topical epinephrine. May be potentiated by quinidine. May inhibit renal excretion of basic drugs and promote excretion of acidic drugs. May increase salicylate toxicity (acidosis). Possible conduction defects, left ventricular failure, or hypotension with calcium channel blockers, digoxin. May block epinephrine.
Taste perversion; ocular burning, stinging, or itching; conjunctival hyperemia, blurred vision, superficial punctate keratitis; possible systemic effects.
Cosopt—10mL; Cosopt PF—60 (single-use 0.2mL containers)