Cosopt Pf

  • Glaucoma

Cosopt Pf Generic Name & Formulations

General Description

Dorzolamide HCl 2%, timolol maleate 0.5%; oph soln; preservative-free.

Pharmacological Class

Carbonic anhydrase inhibitor (sulfonamide) + noncardioselective beta-blocker.

See Also

How Supplied

Cosopt—10mL; Cosopt PF—60 (single-use 0.2mL containers)


Cosopt Pf Indications


Open-angle glaucoma or ocular hypertension where β-blocker alone is inadequate.

Cosopt Pf Dosage and Administration

Adults and Children

<2yrs: not recommended. 1 drop twice daily.

Cosopt Pf Contraindications


Asthma or history of asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock.

Cosopt Pf Boxed Warnings

Not Applicable

Cosopt Pf Warnings/Precautions


Mild-to-moderate COPD or bronchospastic disease, or severe renal impairment: not recommended. Hepatic impairment. Surgery. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Discontinue if ocular effects occur. Soft contact lenses (remove, may reinsert 15 minutes after instillation). Discontinue at 1st sign of cardiac failure. Pregnancy (Cat.C). Nursing mothers: not recommended.

Cosopt Pf Pharmacokinetics

See Literature

Cosopt Pf Interactions


Concomitant oral carbonic anhydrase inhibitors or other topical β-blockers: not recommended. May potentiate systemic β-blockers, reserpine, hypoglycemic agents, and mydriatic effects of topical epinephrine. May be potentiated by quinidine. May inhibit renal excretion of basic drugs and promote excretion of acidic drugs. May increase salicylate toxicity (acidosis). Possible conduction defects, left ventricular failure, or hypotension with calcium channel blockers, digoxin. May block epinephrine.

Cosopt Pf Adverse Reactions

Adverse Reactions

Taste perversion; ocular burning, stinging, or itching; conjunctival hyperemia, blurred vision, superficial punctate keratitis; possible systemic effects.

Cosopt Pf Clinical Trials

See Literature

Cosopt Pf Note

Not Applicable

Cosopt Pf Patient Counseling

See Literature