• Miscellaneous diagnostic tests

Cortrosyn Generic Name & Formulations

General Description

Cosyntropin 0.25mg/mL; pwd for IV or IM inj after reconstitution; preservative-free.

Pharmacological Class

Synthetic ACTH.

How Supplied


Cortrosyn Indications


For use in the screening of patients presumed to have adrenocortical insufficiency.

Cortrosyn Dosage and Administration

Adults and Children

Give by IV, IM inj or IV infusion over 4–8hrs. <2yrs: 0.125mg. ≥2yrs: Usual range: 0.25–0.75mg.

Cortrosyn Contraindications

Not Applicable

Cortrosyn Boxed Warnings

Not Applicable

Cortrosyn Warnings/Precautions


Patients with raised bilirubin or where plasma contains free hemoglobin: falsely high fluorescence measurements may result. Pregnancy (Cat.C). Nursing mothers.

Cortrosyn Pharmacokinetics

See Literature

Cortrosyn Interactions


May accentuate the electrolyte loss associated with diuretics. May exhibit abnormally high plasma cortisol levels if patients taking cortisone, hydrocortisone, spironolactone, estrogens.

Cortrosyn Adverse Reactions

Adverse Reactions

Hypersensitivity reactions (eg, rare, but possible), bradycardia, tachycardia, hypertension, peripheral edema, rash.

Cortrosyn Clinical Trials

See Literature

Cortrosyn Note

Not Applicable

Cortrosyn Patient Counseling

See Literature