Corlopam Generic Name & Formulations
Fenoldopam mesylate 10mg/mL; soln for IV infusion after dilution; contains sodium metabisulfite.
Dopamine D1-like receptor agonist.
Single-dose vial (1mL, 2mL)—1
Adults: for the in-hospital, short-term (up to 48hrs) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. Children: for the in-hospital, short-term (up to 4hrs) reduction in blood pressure.
Corlopam Dosage and Administration
Give by continuous IV infusion. Doses from 0.01–1.6mcg/kg/min have been studied. Initial dose should be titrated upward or downward, no more frequently than every 15mins (and less frequently as goal pressure is approached) to achieve desired therapeutic effect. The recommended increments for titration are 0.05–0.1mcg/kg/min.
Give by continuous infusion pump appropriate for delivery of low infusion rates. Usual starting dose: 0.2mcg/kg/min; increased dosages of up to 0.3–0.5mcg/kg/min every 20–30mins were generally well tolerated.
Corlopam Boxed Warnings
Sulfite sensitivity. Glaucoma. Intraocular hypertension. Increased intracranial pressure. Acute cerebral infarction. Hemorrhage. Monitor BP, electrolytes. Pregnancy. Nursing mothers: not recommended.
Avoid concomitant β-blockers.
Corlopam Adverse Reactions
Headache, flushing, nausea, hypotension, tachycardia, hypokalemia.
Corlopam Clinical Trials
Corlopam Patient Counseling