• Hypertension

Corlopam Generic Name & Formulations

General Description

Fenoldopam mesylate 10mg/mL; soln for IV infusion after dilution; contains sodium metabisulfite.

Pharmacological Class

Dopamine D1-like receptor agonist.

How Supplied

Single-dose vial (1mL, 2mL)—1


Generic Availability


Corlopam Indications


Adults: for the in-hospital, short-term (up to 48hrs) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. Children: for the in-hospital, short-term (up to 4hrs) reduction in blood pressure.

Corlopam Dosage and Administration


Give by continuous IV infusion. Doses from 0.01–1.6mcg/kg/min have been studied. Initial dose should be titrated upward or downward, no more frequently than every 15mins (and less frequently as goal pressure is approached) to achieve desired therapeutic effect. The recommended increments for titration are 0.05–0.1mcg/kg/min.


Give by continuous infusion pump appropriate for delivery of low infusion rates. Usual starting dose: 0.2mcg/kg/min; increased dosages of up to 0.3–0.5mcg/kg/min every 20–30mins were generally well tolerated.

Corlopam Contraindications

Not Applicable

Corlopam Boxed Warnings

Not Applicable

Corlopam Warnings/Precautions


Sulfite sensitivity. Glaucoma. Intraocular hypertension. Increased intracranial pressure. Acute cerebral infarction. Hemorrhage. Monitor BP, electrolytes. Pregnancy. Nursing mothers: not recommended.

Corlopam Pharmacokinetics

See Literature

Corlopam Interactions


Avoid concomitant β-blockers.

Corlopam Adverse Reactions

Adverse Reactions

Headache, flushing, nausea, hypotension, tachycardia, hypokalemia.

Corlopam Clinical Trials

See Literature

Corlopam Note

Not Applicable

Corlopam Patient Counseling

See Literature