Coreg

— THERAPEUTIC DISORDERS TREATED —
  • CHF and arrhythmias
  • Hypertension

Coreg Generic Name & Formulations

General Description

Carvedilol 3.125mg, 6.25mg, 12.5mg, 25mg; tabs.

Pharmacological Class

Noncardioselective beta-blocker/alpha-1 blocker.

See Also

How Supplied

CR caps—30, 90; Tabs—100

Manufacturer

Coreg Indications

Indications

Mild to severe heart failure (HF), to increase survival and reduce hospitalization risk. To reduce cardiovascular mortality post-MI with left ventricular ejection fraction ≤40%.

Coreg Dosage and Administration

Adult

Take with food. Monitor dose increases closely. ≥18yrs: CHF: initially 3.125mg twice daily for 2 weeks, may double dose every 2 weeks if tolerated; mild to moderate HF (>85kg): usual max 50mg twice daily. Reduce dose if pulse <55. Post-MI: initially 6.25mg twice daily; increase to 12.5mg twice daily after 3–10 days if tolerated; then to target dose 25mg twice daily. Low BP or heart rate, or fluid retention: may start at 3.125mg twice daily.

Children

<18yrs: not recommended.

Coreg Contraindications

Contraindications

Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.

Coreg Boxed Warnings

Not Applicable

Coreg Warnings/Precautions

Warnings/Precautions

Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100 mmHg. Initiation of therapy may temporarily worsen signs and symptoms; benefits may be delayed for several weeks; may need increased diuretic dose at first. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Pregnancy. Nursing mothers.

Coreg Pharmacokinetics

See Literature

Coreg Interactions

Interactions

May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.

Coreg Adverse Reactions

Adverse Reactions

Dizziness, edema, hypotension, syncope, bradycardia, AV block, GI upset, hyperglycemia, weight gain, abnormal vision.

Coreg Clinical Trials

See Literature

Coreg Note

Not Applicable

Coreg Patient Counseling

See Literature

Coreg Generic Name & Formulations

General Description

Carvedilol 3.125mg, 6.25mg, 12.5mg, 25mg; tabs.

Pharmacological Class

Noncardioselective beta-blocker/alpha-1 blocker.

See Also

How Supplied

CR caps—30, 90; Tabs—100

Manufacturer

Coreg Indications

Indications

Hypertension.

Coreg Dosage and Administration

Adult

Take with food. ≥18yrs: initially 6.25mg twice daily; may increase as tolerated at 1–2 week intervals to 12.5mg twice daily. Max 25mg twice daily.

Children

<18yrs: not recommended.

Coreg Contraindications

Contraindications

Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.

Coreg Boxed Warnings

Not Applicable

Coreg Warnings/Precautions

Warnings/Precautions

Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100mmHg. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Neonates. Pregnancy (monitor). Nursing mothers.

Coreg Pharmacokinetics

See Literature

Coreg Interactions

Interactions

May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.

Coreg Adverse Reactions

Adverse Reactions

Bradycardia, orthostatic hypotension, dizziness, nasopharyngitis, GI upset, edema.

Coreg Clinical Trials

See Literature

Coreg Note

Not Applicable

Coreg Patient Counseling

See Literature

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