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Coreg Generic Name & Formulations
Legal Class
Rx
General Description
Carvedilol 3.125mg, 6.25mg, 12.5mg, 25mg; tabs.
Pharmacological Class
Noncardioselective beta-blocker/alpha-1 blocker.
See Also
How Supplied
CR caps—30, 90; Tabs—100
Manufacturer
Coreg Indications
Indications
Mild to severe heart failure (HF), to increase survival and reduce hospitalization risk. To reduce cardiovascular mortality post-MI with left ventricular ejection fraction ≤40%.
Coreg Dosage and Administration
Adult
Take with food. Monitor dose increases closely. ≥18yrs: CHF: initially 3.125mg twice daily for 2 weeks, may double dose every 2 weeks if tolerated; mild to moderate HF (>85kg): usual max 50mg twice daily. Reduce dose if pulse <55. Post-MI: initially 6.25mg twice daily; increase to 12.5mg twice daily after 3–10 days if tolerated; then to target dose 25mg twice daily. Low BP or heart rate, or fluid retention: may start at 3.125mg twice daily.
Children
<18yrs: not recommended.
Coreg Contraindications
Contraindications
Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.
Coreg Boxed Warnings
Not Applicable
Coreg Warnings/Precautions
Warnings/Precautions
Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100 mmHg. Initiation of therapy may temporarily worsen signs and symptoms; benefits may be delayed for several weeks; may need increased diuretic dose at first. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Pregnancy. Nursing mothers.
Coreg Pharmacokinetics
See Literature
Coreg Interactions
Interactions
May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.
Coreg Adverse Reactions
Adverse Reactions
Dizziness, edema, hypotension, syncope, bradycardia, AV block, GI upset, hyperglycemia, weight gain, abnormal vision.
Coreg Clinical Trials
See Literature
Coreg Note
Not Applicable
Coreg Patient Counseling
See Literature
Coreg Generic Name & Formulations
Legal Class
Rx
General Description
Carvedilol 3.125mg, 6.25mg, 12.5mg, 25mg; tabs.
Pharmacological Class
Noncardioselective beta-blocker/alpha-1 blocker.
See Also
How Supplied
CR caps—30, 90; Tabs—100
Manufacturer
Coreg Indications
Indications
Hypertension.
Coreg Dosage and Administration
Adult
Take with food. ≥18yrs: initially 6.25mg twice daily; may increase as tolerated at 1–2 week intervals to 12.5mg twice daily. Max 25mg twice daily.
Children
<18yrs: not recommended.
Coreg Contraindications
Contraindications
Cardiogenic shock or decompensated HF requiring intravenous inotropic therapy. Asthma, related bronchospastic conditions. 2nd or 3rd-degree AV block, sick sinus syndrome, or severe bradycardia, unless paced. Severe hepatic impairment.
Coreg Boxed Warnings
Not Applicable
Coreg Warnings/Precautions
Warnings/Precautions
Peripheral vascular disease. Nonallergic bronchospasm. Diabetes (monitor blood glucose). Hyperthyroidism. Monitor renal function in ischemic heart disease, diffuse vascular disease, underlying renal insufficiency, and/or if systolic BP <100mmHg. Avoid abrupt cessation. Prinzmetal's angina. Pheochromocytoma. Elderly. Neonates. Pregnancy (monitor). Nursing mothers.
Coreg Pharmacokinetics
See Literature
Coreg Interactions
Interactions
May be potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone), alcohol (separate by 2 hours). Bradycardia, hypotension with catecholamine depletors (eg, reserpine, MAOIs). Carvedilol levels reduced by rifampin. Increased absorption with cimetidine. Caution with drugs that affect cardiac conduction (esp. diltiazem, verapamil). May potentiate antidiabetic agents. Monitor digoxin, cyclosporine when changing carvedilol dose. Anesthesia.
Coreg Adverse Reactions
Adverse Reactions
Bradycardia, orthostatic hypotension, dizziness, nasopharyngitis, GI upset, edema.
Coreg Clinical Trials
See Literature
Coreg Note
Not Applicable
Coreg Patient Counseling
See Literature
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