• Parkinsonism

Comtan Generic Name & Formulations

General Description

Entacapone 200mg; tabs.

Pharmacological Class

COMT inhibitor.

How Supplied


Comtan Indications


Adjunct to levodopa/ carbidopa in patients with idiopathic Parkinson's disease and end-of-dose wearing off.

Comtan Dosage and Administration


200mg with each dose of levodopa/carbidopa, up to 8 times daily.


Not established.

Comtan Contraindications

Not Applicable

Comtan Boxed Warnings

Not Applicable

Comtan Warnings/Precautions


Dyskinesias. Pre-existing somnolence or sleep disorders. Major psychotic disorder: not recommended. Impulse control disorders; consider dose reduction or discontinue if occurs. Perform skin exams to monitor for melanoma. Discontinue if prolonged diarrhea suspected. Hepatic impairment. Biliary obstruction. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Comtan Pharmacokinetics

See Literature

Comtan Interactions


Nonselective MAOIs: not recommended. Consider reducing levodopa dose. Potentiates CNS depression with alcohol, other CNS depressants. Chelates iron. Cardiac effects with drugs metabolized by COMT (eg, epinephrine, isoproterenol, norepinephrine, dopamine, dobutamine, methyldopa, apomorphine, isoetherine, bitolterol). Caution with drugs that interfere with biliary excretion, glucuronidation, intestinal beta-glucuronidase (eg, probenecid, cholestyramine, erythromycin, rifampicin, ampicillin, chloramphenicol). Monitor INR with warfarin. Reduced efficacy with some antipsychotics.

Comtan Adverse Reactions

Adverse Reactions

Dyskinesia, nausea, urine discoloration, hyperkinesia, diarrhea, abdominal pain, vomiting, dry mouth, back pain, dyspnea, somnolence, anxiety, sweating, purpura, asthenia, taste perversion; rarely: orthostatic hypotension, syncope, hallucinations, rhabdomyolysis, hyperpyrexia and confusion upon withdrawal.

Comtan Clinical Trials

See Literature

Comtan Note

Not Applicable

Comtan Patient Counseling

See Literature