COMBIVIR

Combivir Generic Name & Formulations

Legal Class

General Description

Lamivudine 150mg, zidovudine 300mg; scored tabs.

Pharmacological Class

Nucleoside analogues (reverse transcriptase inhibitors).

How Supplied

Tabs—60

Manufacturer

ViiV Healthcare

Combivir Indications

Indications

HIV-1 infection, in combination with other antiretroviral agents.

Combivir Dosage and Administration

Adults and Children

<30kg: not recommended. ≥30kg: 1 tab twice daily. Hepatic or renal impairment (CrCl <50mL/min): not recommended; use individual components.

Combivir Contraindications

Not Applicable

Combivir Boxed Warnings

Boxed Warning

Hematologic toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis. Exacerbations of hepatitis B.

Combivir Warnings/Precautions

Warnings/Precautions

Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy with prolonged zidovudine use. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Not for treating chronic HBV infection; closely monitor patients co-infected with HBV and HIV for several months after stopping treatment (discontinuing therapy may exacerbate HBV infection); if appropriate, initiate anti-hepatitis B therapy may be warranted. History of pancreatitis. Monitor for lipoatrophy; use alternatives if suspected. Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.

Combivir Pharmacokinetics

See Literature

Combivir Interactions

Interactions

Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin), sorbitol-containing products. Increased hematologic toxicity with ganciclovir, interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon-alpha with or without ribavirin.

Combivir Adverse Reactions

Adverse Reactions

Headache, nausea, malaise, fatigue, nasal symptoms, diarrhea, cough; neutropenia, anemia, lactic acidosis, severe hepatomegaly with steatosis, myopathy, myositis, immune reconstitution syndrome, pancreatitis (discontinue if occurs), lipoatrophy.

Combivir

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