Combigan Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Combigan Indications
Indications
Combigan Dosage and Administration
Adults and Children
Renal Impairment
Combigan has not been studied in patients with renal impairment. A study of patients with renal failure showed that timolol was not readily removed by dialysis. The effect of dialysis on brimonidine pharmacokinetics in patients with renal failure is not known. Following oral administration of timolol maleate, the plasma half-life of timolol is essentially unchanged in patients with moderate renal insufficiency.
Hepatic Impairment
Combigan has not been studied in patients with hepatic impairment.
Combigan Contraindications
Contraindications
Combigan Boxed Warnings
Not Applicable
Combigan Warnings/Precautions
Warnings/Precautions
Combigan Pharmacokinetics
Absorption
Plasma concentrations of brimonidine peaked at 1 to 4 hours after ocular dosing. Peak plasma concentrations of timolol occurred approximately 1 to 3 hours post-dose.
Distribution
The protein binding of timolol is approximately 60%. The protein binding of brimonidine has not been studied.
Elimination
Combigan Interactions
Interactions
Combigan Adverse Reactions
Adverse Reactions
Combigan Clinical Trials
Combigan Note
Not Applicable