• Gout

Colcigel Generic Name & Formulations

General Description

Colchicinum 4X; per gram; 0.25mL per each pump depression; transdermal gel.

Pharmacological Class


How Supplied

Gel—30mL (2 X 15mL bottles)


Generic Availability


Colcigel Indications


Treatment and prophylaxis of acute gout flares.

Colcigel Dosage and Administration


One dose (0.25mL–1mL) = 1–4 pumps. Treatment: Apply 1–4 pumps (0.25mL–1mL) at first sign of gout flare, then 1–4 pumps (0.25mL–1mL) as needed up to every hour; max 6 pumps (1.5mL) in a 1-hour period and 16 pumps (4 doses) in a 24-hour period. May be given during prophylaxis at max 2 pumps at first sign of flare, then 2 pumps hourly up to 3 doses as needed. Wait 12 hours, then resume prophylactic dose. Prophylaxis: >16yrs: Apply 1–3 pumps (0.25mL–0.75mL) twice daily; max 6 pumps (1.5mL) in a 24-hour period. Dose modification in renal or hepatic impairment: see full labeling.


Not recommended.

Colcigel Contraindications


Traumatized skin. Secondary bacterial infection of affected area. Concomitant P-glycoprotein or strong CYP3A4 inhibitors (except fosamprenavir) in severe renal or hepatic impairment (life-threatening toxicity was reported with oral colchicine).

Colcigel Boxed Warnings

Not Applicable

Colcigel Warnings/Precautions


Avoid eyes. Discontinue if irritation, sensitivity, infection, or toxicity is suspected or occurs. Increased risk of neuromuscular toxicity in renal impairment or elderly patients. Renal or hepatic impairment. Undergoing dialysis (treatment): not recommended; (prophylaxis): monitor closely. Pregnancy (Cat.C). Nursing mothers.

Colcigel Pharmacokinetics

See Literature

Colcigel Interactions


See Contraindications. Concomitant P-glycoprotein and/or CYP3A4 inhibitors; monitor for colchicine toxicity. Concomitant statins, gemfibrozil, fibrates, and cyclosporine may potentiate myopathy.

Colcigel Adverse Reactions

Adverse Reactions

Skin irritation at site of application; possible blood dyscrasias, overdosage (may be fatal).

Colcigel Clinical Trials

See Literature

Colcigel Note

Not Applicable

Colcigel Patient Counseling

See Literature