Cleocin Pediatric Granules

  • Bacterial infections

Cleocin Pediatric Granules Generic Name & Formulations

General Description

Clindamycin (as palmitate HCl) 75mg/5mL; for oral soln; cherry flavor.

Pharmacological Class


How Supplied

Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25


Generic Availability


Cleocin Pediatric Granules Indications


Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).

Cleocin Pediatric Granules Dosage and Administration


Use capsule form.


Take with full glass of water. <10kg: at least 37.5mg 3 times daily. Serious: 8–12mg/kg per day. Severe: 13–16mg/kg per day. More severe: 17–25mg/kg per day. Divide into 3–4 equal doses. Beta-hemolytic streptococcal infections: treat for at least 10 days.

Cleocin Pediatric Granules Contraindications

Not Applicable

Cleocin Pediatric Granules Boxed Warnings

Boxed Warning

C. difficile-associated diarrhea.

Cleocin Pediatric Granules Warnings/Precautions


Risk of C. difficile-associated diarrhea; discontinue and treat if colitis is suspected or confirmed. Reserve use for serious infections. Not for treatment of meningitis. Permanently discontinue if severe hypersensitivity reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy. Nursing mothers: consider alternative drug or monitor breast-fed infant for GI effects.

Cleocin Pediatric Granules Pharmacokinetics

See Literature

Cleocin Pediatric Granules Interactions


May potentiate neuromuscular blocking agents; caution. May be potentiated by strong CYP3A4 inhibitors; monitor. May be antagonized by strong CYP3A4 inducers (eg, rifampicin); monitor. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.

Cleocin Pediatric Granules Adverse Reactions

Adverse Reactions

Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, pruritus, angioedema, anaphylaxis, jaundice, acute kidney injury, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).

Cleocin Pediatric Granules Clinical Trials

See Literature

Cleocin Pediatric Granules Note

Not Applicable

Cleocin Pediatric Granules Patient Counseling

See Literature