Cleocin Injection

  • Bacterial infections

Cleocin Injection Generic Name & Formulations

General Description

Clindamycin (as phosphate) 150mg/mL; contains benzyl alcohol.

Pharmacological Class


How Supplied

Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25


Generic Availability


Cleocin Injection Indications


Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).

Cleocin Injection Dosage and Administration


Serious: 0.6–1.2g daily. More severe: 1.2–2.7g/day IM or IV. Both: give in 2–4 equally divided doses; max 600mg per IM inj and 4.8g/day IV. Beta-hemolytic streptococcal infections: treat for at least 10 days.


Neonates: 15–20mg/kg per day. >1 month: 20–40mg/kg per day IM or IV. Both: give in 3–4 equally divided doses. Or: serious infections: 350mg/m2 per day; more severe: 450mg/m2 per day. Beta-hemolytic streptococcal infections: treat for at least 10 days.

Cleocin Injection Contraindications

Not Applicable

Cleocin Injection Boxed Warnings

Boxed Warning

C. difficile-associated diarrhea.

Cleocin Injection Warnings/Precautions


Risk of C. difficile-associated diarrhea; discontinue and treat if colitis is suspected or confirmed. Reserve use for serious infections. Not for treatment of meningitis. Permanently discontinue if severe hypersensitivity reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy. Nursing mothers: consider alternative drug or monitor breast-fed infant for GI effects.

Cleocin Injection Pharmacokinetics

See Literature

Cleocin Injection Interactions


May potentiate neuromuscular blocking agents; caution. May be potentiated by strong CYP3A4 inhibitors; monitor. May be antagonized by strong CYP3A4 inducers (eg, rifampicin); monitor. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.

Cleocin Injection Adverse Reactions

Adverse Reactions

Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, pruritus, angioedema, anaphylaxis, jaundice, acute kidney injury, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).

Cleocin Injection Clinical Trials

See Literature

Cleocin Injection Note

Not Applicable

Cleocin Injection Patient Counseling

See Literature