Cinvanti Generic Name & Formulations
Aprepitant 130mg/18mL; emulsion for IV inj or infusion after dilution; contains egg lecithin, ethanol.
Substance P/NK1 receptor antagonist.
In combination with other antiemetic agents to prevent acute and delayed nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin.
Limitations of Use
Not studied for treating established nausea and vomiting.
Cinvanti Dosage and Administration
Give with dexamethasone and 5-HT3 antagonist (see full labeling). Administer approx. 30mins prior to chemotherapy. Give by IV inj over 2mins (do not dilute) or by IV infusion over 30mins. Moderately emetogenic (3-day regimen): 100mg IV on Day 1, then oral aprepitant 80mg on Days 2 and 3. Moderately to highly emetogenic (single-dose regimen): 130mg IV on Day 1.
Cinvanti Boxed Warnings
Monitor for hypersensitivity reactions; discontinue and treat appropriately if occur; do not reinitiate if symptoms experienced with previous use. Severe hepatic impairment: monitor. Elderly. Pregnancy: avoid. Nursing mothers.
See Contraindications. Monitor concomitant CYP3A4 substrates, including chemotherapy agents (eg, ifosfamide, vinblastine, vincristine). Avoid concomitant moderate-to-strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir, diltiazem) or strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin). Potentiates dexamethasone (reduce its oral dose by 50%), methylprednisolone (reduce its IV dose by 25% and its oral dose by 50%), midazolam, alprazolam, triazolam. May antagonize warfarin (closely monitor INR for 2 weeks after starting each cycle), other CYP2C9 substrates, oral contraceptives (use alternative or backup methods during and for 1 month after last dose).
Cinvanti Adverse Reactions
Headache, fatigue, eructation, infusion-site reactions; anaphylaxis.
Cinvanti Clinical Trials
Cinvanti Patient Counseling