Asthma/COPD:
Recent Updates:
Monograph added.
Indications for CINQAIR:
As add-on maintenance treatment of severe asthma in patients ≥18yrs old, and with an eosinophilic phenotype.
Limitations of Use:
Not for treating other eosinophilic conditions. Not for relief of acute bronchospasm or status asthmaticus.
Adult:
Give by IV infusion over 20–50mins. ≥18yrs: 3mg/kg once every 4 weeks.
Children:
<18yrs: not established.
Warnings/Precautions:
Should be administered by healthcare provider prepared to manage anaphylaxis. Observe patient for a period of time post-infusion; discontinue immediately if severe systemic reactions or anaphylaxis occur. Not for treating acute asthma symptoms or exacerbations. Treat pre-existing helminth infections before initiating therapy; discontinue Cinqair if treatment-resistant infection occurs while on therapy until resolves. Avoid abrupt cessation of systemic or inhaled corticosteroids upon Cinqair initiation; reduce dose gradually if appropriate. Reduction may be associated with systemic withdrawal symptoms and/or unmask previously suppressed conditions. Pregnancy. Nursing mothers.
Pharmacologic Class:
Interleukin-5 antagonist.
Adverse Reactions:
Oropharyngeal pain, elevated CPK, myalgia; anaphylaxis, malignancy.
Generic Availability:
NO
How Supplied:
Single-use vial—1
