• Intermittent claudication

Cilostazol Generic Name & Formulations

General Description

Cilostazol 50mg, 100mg; tabs.

Pharmacological Class

Phosphodiesterase 3 (PDE3) inhibitor.

How Supplied


Cilostazol Indications


Intermittent claudication.

Cilostazol Dosage and Administration


100mg twice daily, ½ hr before or 2 hrs after breakfast and dinner. May reduce to 50mg twice daily if used with CYP3A4 or CYP2C19 inhibitors.


Not established.

Cilostazol Contraindications


Heart failure of any severity.

Cilostazol Boxed Warnings

Boxed Warning

Contraindicated in heart failure patients.

Cilostazol Warnings/Precautions


Risk of tachycardia, palpitation, tachyarrhythmia, or hypotension. Risk of exacerbations of angina pectoris or MI in patients with history of ischemic heart disease. LV outflow tract obstruction: monitor for development of a new systolic murmur or cardiac symptoms. Monitor platelets and WBC periodically. Avoid use in hemostatic disorders or active pathologic bleeding. Moderate-to-severe hepatic impairment. Severe renal impairment. Dialysis. Pregnancy (Cat.C). Nursing mothers: not recommended.

Cilostazol Pharmacokinetics

See Literature

Cilostazol Interactions


Potentiated by drugs that inhibit CYP3A4 (eg, azole antifungals, macrolides, diltiazem, protease inhibitors) or CYP2C19 (eg, omeprazole, fluconazole, fluoxetine, ticlopidine). Avoid grapefruit juice. Cilostazol has been used with aspirin; caution with other antiplatelets, anticoagulants.

Cilostazol Adverse Reactions

Adverse Reactions

Headache, diarrhea, abnormal stools, palpitations, peripheral edema, dizziness, pharyngitis, infection, tachycardia; rare: thrombocytopenia, leukopenia.

Cilostazol Clinical Trials

See Literature

Cilostazol Note

Not Applicable

Cilostazol Patient Counseling

See Literature