• Hyperlipoproteinemias

Cholestyramine Generic Name & Formulations

General Description

Cholestyramine resin (as Cl) 4g; per 9g packet or scoop.

Pharmacological Class

Bile acid sequestrant.

How Supplied

Contact supplier.

Cholestyramine Indications


Hypercholesterolemia alone or with hypertriglyceridemia resistant to dietary management. Reduction in risk of coronary heart disease. Pruritus due to partial biliary obstruction.

Cholestyramine Dosage and Administration


Initially 1 packet or scoop mixed with fluid or food 1–2 times daily. Maintenance: 2–4 packets or scoops divided into 2 doses; max 6 packets or scoops daily. Increase at 4 week intervals.


See full labeling.

Cholestyramine Contraindications


Complete biliary obstruction.

Cholestyramine Boxed Warnings

Not Applicable

Cholestyramine Warnings/Precautions


Obtain baseline serum cholesterol, LDL-C, and triglycerides, and monitor during therapy. May need Vit. A, D, K, and folic acid supplementation with long-term therapy. Exclude secondary causes of hypercholesterolemia (e.g., hypothyroidism, diabetes, nephrotic syndrome, dysproteinemias, obstructive liver disease, alcoholism). Favorable trend in cholesterol reduction usually occurs within 1 month; continue therapy to sustain reduction. Phenylketonuria (Light formulation). Constipation. Hemorrhoids. Pregnancy. Nursing mothers.

Cholestyramine Pharmacokinetics

See Literature

Cholestyramine Interactions


Inhibits absorption of phenylbutazone, warfarin, chlorothiazide, propranolol, tetracycline, penicillin G, phenobarbital, thyroid drugs, digitalis, many others; give other drugs 1–2 hours before or 4–6 hours after. Additive effects with HMG-CoA reductase inhibitors, nicotinic acid.

Cholestyramine Adverse Reactions

Adverse Reactions

Constipation, fecal impaction, aggravation of hemorrhoids, GI disturbances, osteoporosis, Vit. A, D, K, or folic acid deficiencies, increased bleeding, hyperchloremic acidosis, rash, oral or anal irritation.

Cholestyramine Clinical Trials

See Literature

Cholestyramine Note


Formerly known under the brand name Questran.

Cholestyramine Patient Counseling

See Literature