Cholestyramine Generic Name & Formulations
Cholestyramine resin (as Cl) 4g; per 9g packet or scoop.
Bile acid sequestrant.
Hypercholesterolemia alone or with hypertriglyceridemia resistant to dietary management. Reduction in risk of coronary heart disease. Pruritus due to partial biliary obstruction.
Cholestyramine Dosage and Administration
Initially 1 packet or scoop mixed with fluid or food 1–2 times daily. Maintenance: 2–4 packets or scoops divided into 2 doses; max 6 packets or scoops daily. Increase at 4 week intervals.
See full labeling.
Complete biliary obstruction.
Cholestyramine Boxed Warnings
Obtain baseline serum cholesterol, LDL-C, and triglycerides, and monitor during therapy. May need Vit. A, D, K, and folic acid supplementation with long-term therapy. Exclude secondary causes of hypercholesterolemia (e.g., hypothyroidism, diabetes, nephrotic syndrome, dysproteinemias, obstructive liver disease, alcoholism). Favorable trend in cholesterol reduction usually occurs within 1 month; continue therapy to sustain reduction. Phenylketonuria (Light formulation). Constipation. Hemorrhoids. Pregnancy. Nursing mothers.
Inhibits absorption of phenylbutazone, warfarin, chlorothiazide, propranolol, tetracycline, penicillin G, phenobarbital, thyroid drugs, digitalis, many others; give other drugs 1–2 hours before or 4–6 hours after. Additive effects with HMG-CoA reductase inhibitors, nicotinic acid.
Cholestyramine Adverse Reactions
Constipation, fecal impaction, aggravation of hemorrhoids, GI disturbances, osteoporosis, Vit. A, D, K, or folic acid deficiencies, increased bleeding, hyperchloremic acidosis, rash, oral or anal irritation.
Cholestyramine Clinical Trials
Formerly known under the brand name Questran.
Cholestyramine Patient Counseling