Musculoskeletal pain:

Indications for: Chlorzoxazone

As adjunct to rest, physical therapy, and other measures in acute, painful musculoskeletal conditions.

Adult Dosage:

375mg: 1 tab 3–4 times daily; may increase to 2 tabs (750mg) 3–4 times daily if inadequate response. 750mg: ⅓ tab (250mg) 3–4 times daily. Painful musculoskeletal conditions: initially ⅔ tab (500mg) 3–4 times daily; may increase to 1 tab (750mg) 3–4 times daily if inadequate response. May reduce dose based on improvement.

Children Dosage:

Not recommended.

Chlorzoxazone Contraindications:

Known drug intolerance.

Chlorzoxazone Warnings/Precautions:

Monitor for hepatotoxicity; discontinue if hepatic dysfunction or abnormal liver enzymes develop. Known allergies or history of. Discontinue if sensitivity reaction occurs. Pregnancy.

Chlorzoxazone Classification:

Muscle relaxant (central).

Chlorzoxazone Interactions:

Additive effects with concomitant alcohol, other CNS depressants.

Adverse Reactions:

Drowsiness, dizziness, lightheadedness, malaise, overstimulation; rare: skin rash, petechiae, ecchymosis, fatal hepatocellular toxicity.


Formerly known under the brand name Lorzone, Paraflex.

How Supplied:

Contact supplier

Pricing for Chlorzoxazone

500mg tablet (Qty: 90)
Appx. price $26