Chlorpropamide Generic Name & Formulations
Chlorpropamide 100mg, 250mg; scored tabs.
Sulfonylurea (1st generation).
Adjunct to diet in type 2 diabetes.
Chlorpropamide Dosage and Administration
Initially 250mg daily. Elderly: initially 100–125mg daily. Titrate dose. Take with breakfast. Max 750mg daily.
Type 1 diabetes mellitus. Diabetic ketoacidosis.
Chlorpropamide Boxed Warnings
Oral hypoglycemic agents may increase risk of cardiovascular mortality. Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. G6PD deficiency. Monitor urine and blood glucose. Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider insulin instead. Nursing mothers: not recommended.
Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. Disulfiram-like reaction with alcohol.
Chlorpropamide Adverse Reactions
Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria.
Chlorpropamide Clinical Trials
Formerly known under the brand name Diabinese.
Chlorpropamide Patient Counseling