Select therapeutic use:

Malaria:

Indications for Chloroquine:

Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P. malariae, P. ovale, and P. vivax. Prophylaxis of malaria in geographic areas without resistance to chloroquine.

Adult Dosage:

Prophylaxis: 500mg once every 7 days. Treatment: 1g once, then 500mg 6–8hrs later; then 500mg once daily for next 2 days. Low body wt: use children's dose. P. vivax and P. ovale (hypnozoite liver stage): give with concomitant 8-aminoquinoline.

Children Dosage:

Prophylaxis: 8.33mg/kg (max 500mg) once every 7 days. Treatment: 16.7mg/kg (max 1g) once, then 8.33mg/kg (max 500mg) 6, 24 and 36hrs after 1st dose. P. vivax and P. ovale (hypnozoite liver stage): give with concomitant 8-aminoquinoline.

Chloroquine Contraindications:

Retinal or visual field changes in indications other than acute malaria.

Chloroquine Warnings/Precautions:

Prophylaxis: start 2 weeks before and continue for 8 weeks after trip. Monitor for cardiomyopathy esp. at high doses; discontinue if occurs. Cardiac disease. History of ventricular arrhythmias. Uncorrected hypokalemia and/or hypomagnesemia. Bradycardia. Monitor for hypoglycemia. Macular disease. Perform baseline eye exam within the first year of initiation, then annually. Avoid in psoriasis, porphyria. Discontinue if muscular weakness, ocular toxicity, or hearing defects occur. Hepatic, renal, or auditory dysfunction. Alcoholism. Seizure disorders. G6PD deficiency. Monitor CBC, reflexes in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.

Chloroquine Classification:

Aminoquinoline.

Chloroquine Interactions:

Avoid cimetidine. Retinal toxicity with concomitant tamoxifen: not recommended. May potentiate insulin and other antidiabetic drugs: decrease doses of these. Separate ampicillin dose by 2hrs; dosing of antacids or kaolin by 4hrs. Caution with concomitant QT interval prolonging agents, arrhythmogenic, or hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine. Potentiates cyclosporine (monitor). May antagonize praziquantel.

Adverse Reactions:

Retinopathy, maculopathy, macular degeneration, cardiomyopathy, hearing defects, hypoglycemia, acute extrapyramidal disorders, blood dyscrasias, muscular weakness, GI upset, skin reactions, neuropsychiatric disorders.

Note:

Formerly known under the brand name Aralen.

How Supplied:

Contact supplier

Protozoal infections:

Indications for Chloroquine:

Extraintestinal amebiasis (use with intestinal amebicide).

Adult Dosage:

1g daily for 2 days, then 500mg daily for at least 2–3 weeks.

Children Dosage:

See full labeling.

Chloroquine Contraindications:

Retinal or visual field changes in indications other than acute malaria.

Chloroquine Warnings/Precautions:

Prophylaxis: start 2 weeks before and continue for 8 weeks after trip. Monitor for cardiomyopathy esp. at high doses; discontinue if occurs. Cardiac disease. History of ventricular arrhythmias. Uncorrected hypokalemia and/or hypomagnesemia. Bradycardia. Monitor for hypoglycemia. Macular disease. Perform baseline eye exam within the first year of initiation, then annually. Avoid in psoriasis, porphyria. Discontinue if muscular weakness, ocular toxicity, or hearing defects occur. Hepatic, renal, or auditory dysfunction. Alcoholism. Seizure disorders. G6PD deficiency. Monitor CBC, reflexes in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.

Chloroquine Classification:

Aminoquinoline.

Chloroquine Interactions:

Avoid cimetidine. Retinal toxicity with concomitant tamoxifen: not recommended. May potentiate insulin and other antidiabetic drugs: decrease doses of these. Separate ampicillin dose by 2hrs; dosing of antacids or kaolin by 4hrs. Caution with concomitant QT interval prolonging agents, arrhythmogenic, or hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine. Potentiates cyclosporine (monitor). May antagonize praziquantel.

Adverse Reactions:

Retinopathy, maculopathy, macular degeneration, cardiomyopathy, hearing defects, hypoglycemia, acute extrapyramidal disorders, blood dyscrasias, muscular weakness, GI upset, skin reactions, neuropsychiatric disorders.

Note:

Formerly known under the brand name Aralen.

How Supplied:

Contact supplier