Mood disorders:

Indications for: Chlordiazepoxide/Amitriptyline HCl

Moderate to severe depression associated with moderate to severe anxiety.

Adult Dosage:

Individualize. Initially 3–4 tabs daily in divided doses (with largest portion taken at bedtime). 10mg/25mg tabs: may be increased to 6 tabs daily. Elderly: reduce dose.

Children Dosage:

Not established.

Chlordiazepoxide/Amitriptyline HCl Contraindications:

During or within 14 days of MAOIs. Acute post MI.

Boxed Warning:

Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions. Suicidal thoughts and behaviors.

Chlordiazepoxide/Amitriptyline HCl Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor closely for clinical worsening, suicidality, or unusual changes in behavior. Activation of mania/hypomania; screen patients for bipolar disorder. Discontinue several days before surgery. History of urinary retention, seizures, angle-closure glaucoma. Cardiovascular disorders. Hyperthyroidism. Renal or hepatic impairment. Monitor LFTs, CBCs during long-term therapy. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Withdraw gradually. Write Rx for smallest practical amount. Drug or alcohol abusers. Elderly. Debilitated. Pregnancy (during the 1st trimester), nursing mothers: not recommended.

Chlordiazepoxide/Amitriptyline HCl Classification:

Benzodiazepine + tricyclic.

Chlordiazepoxide/Amitriptyline HCl Interactions:

See Contraindications. Hyperpyretic crisis, severe convulsions, and death with MAOIs. Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Concomitant CYP2D6 inhibitors: may need to adjust dose. During or within 5 weeks of fluoxetine: not recommended. Potentiated by cimetidine, topiramate. Potentiates CNS depression with alcohol, other CNS depressants. Caution with concomitant SSRIs, ECT. May block antihypertensives (eg, guanethidine).

Adverse Reactions:

Drowsiness, dry mouth, constipation, blurred vision, dizziness, bloating, vivid dreams, impotence, tremor, confusion, nasal congestion; rare: granulocytopenia, jaundice, hepatic dysfunction. MI, stroke, arrhythmias, sinus tachycardia, prolongation of conduction time possible with high doses, withdrawal reactions.


Formerly known under the brand names Limbitrol, Limbitrol DS.

How Supplied:

Contact supplier.