• Inborn errors of metabolism

Cerezyme Generic Name & Formulations

General Description

Imiglucerase 200 Units, 400 Units; per vial; pwd; for IV infusion after reconstitution.

Pharmacological Class

Beta-glucocerebrosidase analogue.

How Supplied



Cerezyme Indications


For long-term enzyme replacement therapy in patients with confirmed Type 1 Gaucher disease that results in one or more of the following conditions: 1) anemia; 2) thrombocytopenia; 3) bone disease; 4) hepatomegaly or splenomegaly.

Cerezyme Dosage and Administration

Adults and Children

<2yrs: not recommended. ≥2yrs: Give by IV infusion over 1–2 hours. Individualize. Initial dose range: 2.5 Units/kg 3 times a week to 60 Units/kg once every 2 weeks.

Cerezyme Contraindications

Not Applicable

Cerezyme Boxed Warnings

Not Applicable

Cerezyme Warnings/Precautions


Monitor periodically for IgG antibody formation during the first year. Patients previously treated with Ceredase (alglucerase inj) who have developed antibody or hypersensitivity to Ceredase. Monitor for pulmonary hypertension, pneumonia. Pregnancy (Cat.C). Nursing mothers.

Cerezyme Pharmacokinetics

See Literature

Cerezyme Interactions

Not Applicable

Cerezyme Adverse Reactions

Adverse Reactions

GI upset, abdominal pain, rash, pruritus, fatigue, headache, fever, dizziness, chills, backache, tachycardia, inj site reactions, hypersensitivity. Also children: dyspnea, flushing, coughing,

Cerezyme Clinical Trials

See Literature

Cerezyme Note

Not Applicable

Cerezyme Patient Counseling

See Literature