• Miscellaneous hematological agents

Ceprotin Generic Name & Formulations

General Description

Protein C concentrate (human) 500 IU, 1000 IU; per vial; lyophilized pwd for IV infusion after reconstitution; contains albumin; preservative-free.

Pharmacological Class

Anticoagulant protein.

How Supplied

Single-use vial—1 (w. diluent, supplies)

Ceprotin Indications


Prevention and treatment of venous thrombosis and purpura fulminans in severe congenital Protein C deficiency.

Ceprotin Dosage and Administration

Adults and Children

Give by IV infusion only. <10kg: max rate 0.2mL/kg/min; ≥10kg: max rate 2mL/min. Individualize. Acute episodes/short term prophylaxis: initially 100–120 IU/kg, then 60–80 IU/kg every 6hrs for 3 doses (adjust dose to maintain target peak protein C activity of 100%); maintenance: 45–60 IU/kg every 6 or every 12hrs (maintain trough protein C level above 25% for duration of therapy); continue until desired anticoagulation achieved. Long-term prophylaxis: 45–60 IU/kg every 12hrs (maintain trough protein C level above 25%). Switching to oral anticoagulants: start with low dose; continue protein C replacement until stable anticoagulation obtained.

Ceprotin Contraindications

Not Applicable

Ceprotin Boxed Warnings

Not Applicable

Ceprotin Warnings/Precautions


Measure protein C activity before and during treatment; if acute thrombotic event occurs, obtain protein C activity measurement before the next injection until patient is stable. Contains human albumin; monitor for possible viral disease and Creutzfeldt-Jakob disease transmission. Mouse protein allergy. Contains heparin; if heparin-induced thrombocytopenia suspected, check platelet counts immediately, consider discontinuing. Renal impairment and/or sodium-restricted (max daily dose contains sodium >200mg). Labor & delivery. Pregnancy. Nursing mothers.

Ceprotin Pharmacokinetics

See Literature

Ceprotin Interactions


Increased risk of bleeding with concurrent anticoagulants, tissue plasminogen activator.

Ceprotin Adverse Reactions

Adverse Reactions

Rash, itching, lightheadedness; hypersensitivity reactions (discontinue if occurs).

Ceprotin Clinical Trials

See Literature

Ceprotin Note


Report all infections suspected to be transmitted by Ceprotin to (866) 888-2472.

Ceprotin Patient Counseling

See Literature