• Seizure disorders

Celontin Generic Name & Formulations

General Description

Methsuximide 300mg; caps.

Pharmacological Class


How Supplied



Celontin Indications


Absence (petit mal) seizures refractory to other drugs.

Celontin Dosage and Administration

Adults and Children

Individualize. Initially 300mg once daily for the 1st week; may increase at weekly intervals by 300mg/day for 3 weeks based on response; max 1.2g daily. May be administered with other anticonvulsants.

Celontin Contraindications

Not Applicable

Celontin Boxed Warnings

Not Applicable

Celontin Warnings/Precautions


Monitor blood counts periodically, esp. if signs/symptoms of infection develop. Hepatic or renal impairment; monitor urine and liver function tests. Monitor for new or worsening depression, suicidal thoughts and/or unusual changes in behavior; withdraw gradually if occur. May increase frequency of grand mal seizures when used alone in mixed seizure type. Avoid abrupt cessation. Pregnancy.

Celontin Pharmacokinetics

See Literature

Celontin Interactions


May potentiate phenytoin, phenobarbital; monitor periodically.

Celontin Adverse Reactions

Adverse Reactions

Nausea, vomiting, diarrhea, weight loss, abdominal pain, constipation, blood dyscrasias, confusion, depression, drowsiness, ataxia, dizziness, rash, urticaria, hyperemia, proteinuria, hematuria; rare: SLE, suicidal ideation, psychosis.

Celontin Clinical Trials

See Literature

Celontin Note

Not Applicable

Celontin Patient Counseling

See Literature