• Bacterial infections

Ceftriaxone Generic Name & Formulations

General Description

Ceftriaxone sodium 500mg, 1g; IM or IV inj; sodium content 3.6mEq/g.

Pharmacological Class


How Supplied

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Ceftriaxone Indications


Susceptible bacterial infections of the lower respiratory tract, skin and skin structure, bone and joint, acute otitis media, UTIs, septicemia, pelvic inflammatory disease (PID), intraabdominal infections, meningitis, uncomplicated gonorrhea. Surgical prophylaxis.

Ceftriaxone Dosage and Administration


1–2g IM or IV once daily or in 2 equally divided doses; max 4g/day. Gonorrhea: 250mg IM once. Surgery: a single dose of 1g IV 0.5–2hrs pre-op.


50–75mg/kg per day in equally divided doses every 12hrs; max 2g/day. Skin and skin structures: may give once daily or in 2 equally divided doses every 12hrs; max 2g/day. Meningitis: 100mg/kg (max 4g) for 1 dose, then 100mg/kg per day (max 4g/day) once daily or in 2 equally divided doses every 12hrs for 7–14 days. Otitis media: 50mg/kg (max 1g) IM once.

Ceftriaxone Contraindications


Hyperbilirubinemic or premature neonates. Concomitant calcium-containing IV solutions or products in neonates. Ceftriaxone solutions containing lidocaine for IV administration.

Ceftriaxone Boxed Warnings

Not Applicable

Ceftriaxone Warnings/Precautions


Penicillin or other beta-lactam allergy. Discontinue if urolithiasis, oliguria, renal or gallbladder sonographic abnormalities, signs or symptoms occur. Renal failure: monitor; decrease dose if drug accumulation occurs. Chronic hepatic disease or malnutrition (impaired Vit. K synthesis or storage): monitor prothrombin time. Both hepatic and significant renal impairment: usual max 2g/day. Ensure adequate hydration. Pregnancy (Cat.B). Nursing mothers.

Ceftriaxone Pharmacokinetics

See Literature

Ceftriaxone Interactions


See Contraindications. Increased risk of bleeding with concomitant Vit. K antagonists. May be potentiated by probenecid. Precipitation can form with calcium-containing solutions; avoid. Monitor for methemoglobinemia with concomitant local anesthetics (eg, lidocaine). May cause false (+) Clinitest or Coomb's test.

Ceftriaxone Adverse Reactions

Adverse Reactions

Local reactions, hematologic effects (eg, eosinophilia), rash, diarrhea, elevated liver enzymes; hypersensitivity reactions, C.difficile-associated diarrhea, hemolytic anemia, pancreatitis.

Ceftriaxone Clinical Trials

See Literature

Ceftriaxone Note


Formerly known under the brand name Rocephin.

Ceftriaxone Patient Counseling

See Literature