• Bacterial infections

Cefotaxime Generic Name & Formulations

General Description

Cefotaxime sodium 500mg, 1g, 2g, 10g; IM or IV inj; sodium content 2.2mEq/g.

Pharmacological Class


How Supplied

Contact supplier


Cefotaxime Indications


Susceptible bacteremia, septicemia, lower respiratory and genitourinary tracts, skin and skin structure, bone and joint, gynecologic, CNS (eg, meningitis), intraabdominal infections. Surgical prophylaxis.

Cefotaxime Dosage and Administration


Uncomplicated infections: 1g every 12 hours. Moderate-to-severe infections: 1–2g every 8 hours. Infections commonly needing a higher dosage (eg, septicemia): 2g IV every 6–8 hours. Life-threatening infections: 2g IV every 4 hours. Gonococcal urethritis or cervicitis: 0.5g IM once. Rectal gonorrhea: 0.5g (women) or 1g (men) IM once. All: max 12g/day. Post-op prophylaxis: give 1g as single dose 30–90mins before surgery. Cesarean section: 1st dose: 1g IV as soon as umbilical cord clamped; 2nd and 3rd dose: 1g at 6 and 12 hours after 1st dose. CrCl <20mL/min/1.73m2: consider reducing dose by one-half.


Neonates up to 1 week of age: 50mg/kg IV every 12 hours. 1–4 weeks of age: 50mg/kg IV every 8 hours. Over 1 month of age (<50kg): 50–180mg/kg in 4–6 equally divided doses. ≥50kg: as adult; max 12g/day.

Cefotaxime Contraindications

Not Applicable

Cefotaxime Boxed Warnings

Not Applicable

Cefotaxime Warnings/Precautions


Penicillin or other allergy. Monitor blood counts in treatments >10 days. Renal impairment, reduce dose. GI disease (esp. colitis). Avoid extravasation. Pregnancy (Cat.B). Nursing mothers.

Cefotaxime Pharmacokinetics

See Literature

Cefotaxime Interactions


Increased nephrotoxicity with concomitant aminoglycosides, NSAIDs, furosemide. Potentiated by probenecid; avoid cefotaxime doses >6g/day. May cause false (+) Fehling's or Benedict's soln, Clinitest, or Coomb's test.

Cefotaxime Adverse Reactions

Adverse Reactions

Inj site reactions, colitis, diarrhea, nausea, vomiting, hypersensitivity (discontinue if occurs); blood dyscrasias, elevated liver enzymes (rare).

Cefotaxime Clinical Trials

See Literature

Cefotaxime Note


Formerly known under the brand name Claforan.

Cefotaxime Patient Counseling

See Literature