Cefotan Generic Name & Formulations
Legal Class
Rx
General Description
Cefotetan disodium 1g, 2g; IM or IV inj; sodium content 3.5mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Vials—10
Manufacturer
Generic Availability
YES
Cefotan Indications
Indications
Susceptible lower respiratory tract or urinary tract, skin and skin structure, bone and joint, gynecologic, intraabdominal infections. Surgical prophylaxis.
Cefotan Dosage and Administration
Adult
IV: inject over 3–5mins. UTI: 500mg IV or IM every 12hrs or 1–2g IV or IM every 12–24hrs. Mild to moderate skin and skin structures: 2g IV every 24hrs or 1g IV or IM every 12hrs. Severe skin and skin structure: 2g IV every 12hrs. Other sites: 1–2g IV or IM every 12hrs. Severe: 2g IV every 12hrs. Life threatening: 3g IV every 12hrs; max 6g/day. Prophylaxis: 1–2g IV once 30–60 mins before surgery. CrCl <30mL/min: reduce dose or frequency, see full labeling. Hemodialysis: give ¼ of the usual dose every 24hrs on days between dialysis and ½ the usual dose on dialysis days.
Children
Not established.
Cefotan Contraindications
Contraindications
Previous cephalosporin-associated hemolytic anemia.
Cefotan Boxed Warnings
Not Applicable
Cefotan Warnings/Precautions
Warnings/Precautions
Penicillin or other allergy. Discontinue if allergic reaction occurs. Have epinephrine and other emergency measures available. Renal impairment. Renal or hepatobiliary dysfunction, poor nutritional state, cancer patients, or elderly: monitor prothrombin time. Monitor for hemolytic anemia or superinfection with prolonged use. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers.
Cefotan Pharmacokinetics
See Literature
Cefotan Interactions
Interactions
Avoid alcohol for 72 hours after dosing. Increased nephrotoxicity with concomitant aminoglycoside; monitor renal function. May cause false (+) Clinitest, Benedict's or Fehling's soln. May interfere with creatinine tests.
Cefotan Adverse Reactions
Adverse Reactions
Diarrhea, nausea, rash, itching, local reactions, anaphylaxis, blood dyscrasias, elevated liver enzymes, fever; C. difficile-associated diarrhea.
Cefotan Clinical Trials
See Literature
Cefotan Note
Not Applicable
Cefotan Patient Counseling
See Literature
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