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Cefazolin Generic Name & Formulations
Legal Class
Rx
General Description
Cefazolin (as sodium) 500mg/vial, 1g/vial; pwd for IM or IV inj or IV infusion after reconstitution and dilution; sodium content 48mg/g cefazolin.
Pharmacological Class
Cephalosporin.
How Supplied
Contact supplier.
Manufacturer
Cefazolin Indications
Indications
Susceptible bacterial infections including septicemia, respiratory, biliary or GU tract, skin and skin structure, bone and joint, endocarditis. Surgical prophylaxis.
Cefazolin Dosage and Administration
Adult
Pneumococcal pneumonia: 500mg every 12 hours. Mild infections: 250–500mg every 8 hours; moderate to severe infections: 500mg–1g every 6–8 hours. Severe, life-threatening infections (eg, endocarditis, septicemia): 1–1.5g every 6 hours; max 12g/day. UTIs: 1g every 12 hours. Prophylaxis: see literature. Renal impairment (give initial loading dose): (CrCl 35–54mL/min): reduce dosing frequency to at least 8 hour intervals; (CrCl 11–34mL/min): reduce dose by 50%, give every 12 hours; (CrCl <10mL/min): reduce dose by 50%, give every 18–24 hours. Peritoneal dialysis: see literature.
Children
<1 month: not recommended. ≥1 month: Mild to moderately severe infections: 25–50mg/kg per day in 3–4 divided doses. Severe infections: max 100mg/kg per day. Renal impairment (give initial loading dose): (CrCl 40–70mL/min): reduce dose by 40%; give every 12 hours; (CrCl 20–40mL/min): reduce dose by 75%, give every 12 hours; (CrCl 5–20mL/min): reduce dose by 90%, give every 24 hours.
Cefazolin Contraindications
Not Applicable
Cefazolin Boxed Warnings
Not Applicable
Cefazolin Warnings/Precautions
Warnings/Precautions
Penicillin or other allergy. Renal impairment: reduce dose. GI disease (esp. colitis). Monitor PT in patients at risk (eg, renal or hepatic impairment, poor nutritional state, long term use, or anticoagulant therapy). Pregnancy (Cat.B). Nursing mothers.
Cefazolin Pharmacokinetics
See Literature
Cefazolin Interactions
Interactions
Potentiated by probenecid. May cause false (+) Clinitest, Benedict's, or Fehling's soln.
Cefazolin Adverse Reactions
Adverse Reactions
GI upset, anaphylaxis, rash, pruritus, local reactions, blood dyscrasias, elevated liver enzymes.
Cefazolin Clinical Trials
See Literature
Cefazolin Note
Notes
Formerly known under the brand names Ancef, Kefzol.
Cefazolin Patient Counseling
See Literature
