Cardura Xl

  • Benign prostatic hyperplasia/urinary retention

Cardura Xl Generic Name & Formulations

General Description

Doxazosin (as mesylate) 4mg, 8mg; ext-rel tabs.

Pharmacological Class

Alpha-1 blocker.

How Supplied



Cardura Xl Indications



Cardura Xl Dosage and Administration


Swallow whole. Take w. breakfast. Initially 4mg once daily; may titrate after 3–4 weeks to max 8mg/day. If therapy is stopped for several days, restart at 4mg once daily. Switching from Cardura to Cardura XL: initially 4mg once daily; do not take final evening dose of Cardura. Concomitant PDE-5 inhibitors: initiate at lowest dose.


Not established.

Cardura Xl Contraindications

Not Applicable

Cardura Xl Boxed Warnings

Not Applicable

Cardura Xl Warnings/Precautions


Severe hepatic impairment: not recommended. Mild or moderate hepatic impairment. Syncope. Symptomatic hypotension. Exclude prostate cancer. Severe GI narrowing. Coronary insufficiency; discontinue if angina pectoris appears or worsen. Cataract surgery (intraoperative floppy iris syndrome possible). Elderly. Pregnancy, nursing mothers: not indicated for females.

Cardura Xl Pharmacokinetics

See Literature

Cardura Xl Interactions


Caution with strong CYP3A4 inhibitors (eg, atanazavir, clarithromycin, indinavir, ketoconazole, itraconazole, nefazodone, others). Additive hypotension with concomitant PDE-5 inhibitors.

Cardura Xl Adverse Reactions

Adverse Reactions

Headache, dizziness, asthenia, hypotension, dyspnea, postural hypotension, somnolence, respiratory or urinary tract infections; rare: priapism.

Cardura Xl Clinical Trials

See Literature

Cardura Xl Note

Not Applicable

Cardura Xl Patient Counseling

See Literature