• Angina

Cardizem Generic Name & Formulations

General Description

Diltiazem HCl 30mg, 60mg+, 90mg+, 120mg+; tabs; +scored.

Pharmacological Class

Calcium channel blocker (CCB) (benzothiazepine).

How Supplied

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg—100, 500; 60mg, 90mg, 120mg—100

Cardizem Indications


Vasospastic and chronic stable angina.

Cardizem Dosage and Administration


Swallow whole. 30mg 4 times daily before meals and at bedtime. May increase gradually every 1–2 days; max 360mg/day in divided doses. Concomitant simvastatin: max 240mg/day.


Not established.

Cardizem Contraindications


Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Cardizem Boxed Warnings

Not Applicable

Cardizem Warnings/Precautions


CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Cardizem Pharmacokinetics

See Literature

Cardizem Interactions


Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.

Cardizem Adverse Reactions

Adverse Reactions

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.

Cardizem Clinical Trials

See Literature

Cardizem Note

Not Applicable

Cardizem Patient Counseling

See Literature